A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF.

Frontiers in Immunology
Joseph R TumangThomas L Rothstein

Abstract

B1 B cells defend against infectious microorganisms by spontaneous secretion of broadly reactive "natural" immunoglobulin that appears in the absence of immunization. Among many distinguishing characteristics, B1 B cells display evidence of activation that includes phosphorylated STAT3. In order to identify the origin of pSTAT3 we examined interleukin-2 receptor (IL-2R) expression on B1 cells. We found that some (about 1/5) B1a cells express the IL-2R α chain, CD25. Although lacking CD122 and unresponsive to IL-2, B1a cells marked by CD25 express increased levels of activated signaling intermediates, interruption of which results in diminished CD25. Further, CD25⁺ B1a cells contain most of the pSTAT3 found in the B1a population as a whole. Moreover, CD25⁺ B1a cells express leukemia inhibitory factor receptor (LIFR), and respond to LIF by upregulating pSTAT3. Together, these results define a new subset of B1a cells that is marked by activation-dependent CD25 expression, expresses substantial amounts of activated STAT3, and contains a functional LIFR.

Citations

May 20, 2015·Annals of the New York Academy of Sciences·Hongsheng WangHerbert C Morse
May 23, 2013·Annals of the New York Academy of Sciences·Thomas L RothsteinHiroaki Kaku
Aug 12, 2017·Frontiers in Immunology·Nichol E HolodickAna María Hernández
Jul 6, 2017·Frontiers in Immunology·Hiroaki KakuThomas L Rothstein
Nov 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroaki KakuThomas L Rothstein

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Methods Mentioned

BETA
flow cytometry
PCR

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