PMID: 8960121Aug 1, 1996Paper

A CD30 responsive element in the germline epsilon promoter that is distinct from and inhibitory to the CD40 response element

Molecular Immunology
M D JumperK Meek

Abstract

Germline epsilon (I epsilon) transcription is requisite for IgE switch recombination. I epsilon transcription is markedly increased by ligation of CD40 and/or by IL-4 stimulation. By contrast, we found previously that stimulation through CD30 inhibits I epsilon transcription in EBV-transformed B cell lines. To characterize the molecular mechanisms involved in these contradictory events, the promoter elements that are responsible for I epsilon transcriptional regulation were determined using stable CAT reporter gene constructs. The results define a 95 bp CD30 responsive element (CD30RE) located 5' of the previously defined CD40 responsive element (CD40RE) that resides within the same 95 bp fragment as the IL-4RE and ablates CD40L induced I epsilon promoter activity. However, IL-4 overrides the inhibitory effect of CD30L. These results define a CD30RE and provide further evidence for the complex regulation of I epsilon transcription by various members of the CD40L/TNF alpha family of molecules.

References

Aug 1, 1995·European Journal of Immunology·K D ShanebeckK H Grabstein
Jul 1, 1993·The Journal of Experimental Medicine·Y Wakatsuki, W Strober

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