A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure.

American Journal of Physiology. Endocrinology and Metabolism
Monica L WatsonJ David Furlow

Abstract

Glucocorticoids (GCs) are important regulators of skeletal muscle mass, and prolonged exposure will induce significant muscle atrophy. To better understand the mechanism of skeletal muscle atrophy induced by elevated GC levels, we examined three different models: exogenous synthetic GC treatment [dexamethasone (DEX)], nutritional deprivation, and denervation. Specifically, we tested the direct contribution of the glucocorticoid receptor (GR) in skeletal muscle atrophy by creating a muscle-specific GR-knockout mouse line (MGR(e3)KO) using Cre-lox technology. In MGR(e3)KO mice, we found that the GR is essential for muscle atrophy in response to high-dose DEX treatment. In addition, DEX regulation of multiple genes, including two important atrophy markers, MuRF1 and MAFbx, is eliminated completely in the MGR(e3)KO mice. In a condition where endogenous GCs are elevated, such as nutritional deprivation, induction of MuRF1 and MAFbx was inhibited, but not completely blocked, in MGR(e3)KO mice. In response to sciatic nerve lesion and hindlimb muscle denervation, muscle atrophy and upregulation of MuRF1 and MAFbx occurred to the same extent in both wild-type and MGR(e3)KO mice, indicating that a functional GR is not required to induce ...Continue Reading

References

May 1, 1990·The American Journal of Physiology·L StojanovskaJ Proietto
Dec 1, 1982·The American Journal of Physiology·R L RuffA M Gordon
Feb 27, 1995·Molecular and Cellular Endocrinology·D H Hong, N E Forsberg
Jul 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·T Seene
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·E J KellyR D Palmiter
Feb 12, 1998·The American Journal of Physiology·S C HoblerP O Hasselgren
May 18, 1999·The American Journal of Physiology·W E MitchS R Price
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P O Hasselgren
Dec 10, 1999·The Journal of Endocrinology·R RoomanS C van Buul-Offers
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·O J ShahL S Jefferson
Mar 21, 2000·Genesis : the Journal of Genetics and Development·C KellendonkF Tronche
May 22, 2002·Endocrinology·Christoph KellendonkEckhart Simon
May 2, 2003·American Journal of Physiology. Endocrinology and Metabolism·Kun MaBehrouz Salehian
Dec 12, 2003·The British Journal of Nutrition·Jean-François DumasPatrick Ritz
Mar 24, 2004·Genes & Development·François TroncheGünther Schütz
Aug 28, 2004·Diabetes·Emilie GesinaBernadette Breant
Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Maureen P BoyleLouis J Muglia
Apr 21, 2007·The Journal of Clinical Investigation·Jan P TuckermannGünther Schütz
Oct 24, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Eva-Maria RisoTeet Seene
Feb 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Liping SunAlan L Schwartz
Mar 11, 2008·Archives of Biochemistry and Biophysics·J BurénJ Jensen
Jul 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·David S WaddellSue C Bodine
Dec 9, 2008·Biochemical and Biophysical Research Communications·Weidong ZhaoChristopher Cardozo
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alex Y -L SoBrian J Feldman

❮ Previous
Next ❯

Citations

Mar 26, 2013·Molecular and Cellular Endocrinology·Taiyi KuoJen-Chywan Wang
Mar 26, 2013·Molecular and Cellular Endocrinology·Adam J Rose, Stephan Herzig
May 29, 2014·Physiology & Behavior·John L ShannonhouseCaurnel Morgan
Dec 17, 2015·Annual Review of Physiology·Maria A SactaInez Rogatsky
Feb 16, 2016·International Journal of Molecular Sciences·Terry D HindsJoseph S Marino
Oct 27, 2015·Molecular Metabolism·Jürgen G OkunAdam J Rose
Jun 29, 2013·The International Journal of Biochemistry & Cell Biology·O SchakmanJ P Thissen
Jan 9, 2014·Chronobiology International·Reiko NakaoKatsutaka Oishi
Jun 15, 2014·General and Comparative Endocrinology·Christine R Lattin, L Michael Romero
Jun 27, 2013·The International Journal of Biochemistry & Cell Biology·Sue C Bodine
Oct 28, 2015·Molecular and Cellular Endocrinology·Michaël R LaurentFerran Jardí
Dec 17, 2014·Biochimica Et Biophysica Acta·Nicholas A M PanstersRamon C J Langen
Aug 28, 2014·Current Opinion in Supportive and Palliative Care·Judith J M CeelenAnnemie M W J Schols
Aug 25, 2017·International Journal of Molecular Sciences·Fred Lühder, Holger M Reichardt
Oct 14, 2017·Endocrinology·Shannon Whirledge, Donald B DeFranco
Jul 3, 2018·Clinical Reviews in Bone and Mineral Metabolism·Amy Y SatoTeresita Bellido
Aug 7, 2014·American Journal of Physiology. Endocrinology and Metabolism·Sue C Bodine, Leslie M Baehr
Nov 28, 2014·Journal of Applied Physiology·C C de TheijeS E Köhler
Feb 13, 2020·International Journal of Molecular Sciences·Hongwei GengLinlin Hao
Jun 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Theodore P BraunDaniel L Marks
Apr 29, 2014·Molecular Endocrinology·Rucha PatelCarolyn L Cummins
Jul 25, 2014·Endocrinology·Sybille D ReichardtHolger M Reichardt
Mar 21, 2015·Journal of Applied Physiology·Jacqueline L BeaudryMichael C Riddell
Mar 2, 2017·American Journal of Physiology. Endocrinology and Metabolism·Seol-Hee KangInkyeom Kim
Sep 17, 2020·International Journal of Molecular Sciences·Dulce Peris-MorenoCécile Polge
Feb 13, 2016·Journal of Applied Physiology·Ruth K Globus, Emily Morey-Holton
Sep 3, 2019·Biological & Pharmaceutical Bulletin·Hiroshi WatanabeToru Maruyama
Nov 5, 2019·Frontiers in Immunology·Mubashir AhmadJan Tuckermann
Jan 30, 2021·Nature Chemical Biology·Nelson E BrunoKendall W Nettles
Oct 27, 2020·Journal of Neuromuscular Diseases·Mattia QuattrocelliElizabeth M McNally
Mar 10, 2021·Journal of Cachexia, Sarcopenia and Muscle·Tania Cid-DíazJesus P Camiña

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.