A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function: Pre-Clinical Study in the Porcine Myocardial Infarction Model

JACC. Basic to Translational Science
Isaac Perea-GilAntoni Bayes-Genis

Abstract

Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.

References

Jun 1, 1989·Journal of the American College of Cardiology·K T Weber
May 14, 1993·Science·R Langer, J P Vacanti
Sep 14, 2006·Tissue Engineering·Wilhelm ErdbrüggerGeorg Pauli
May 15, 2007·Circulation Research·Jeffrey M GimbleBruce A Bunnell
Jun 28, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M RadisicG Vunjak-Novakovic
Sep 23, 2008·The Annals of Thoracic Surgery·Rupak MukherjeeFrancis G Spinale
Apr 4, 2009·Science·Olaf BergmannJonas Frisén
Jul 18, 2009·Biomaterials·Jennifer M SingelynKaren L Christman
Aug 27, 2009·Acta Physiologica Hungarica·N N HokeRakesh C Kukreja
Feb 8, 2011·Biomaterials·Peter M CrapoStephen F Badylak
Mar 23, 2011·Annual Review of Biomedical Engineering·Stephen F BadylakKorkut Uygun
Apr 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Amandine F G Godier-FurnémontGordana Vunjak-Novakovic
May 17, 2011·Annual Review of Biomedical Engineering·Gordana Vunjak-NovakovicKenneth R Chien
May 18, 2011·Cardiovascular Research·Carolina Gálvez-MontónAntoni Bayes-Genis
Sep 3, 2011·Journal of the American College of Cardiology·Bodo-Eckehard Strauer, Gustav Steinhoff
Jun 20, 2012·International Journal of Cardiology·Antoni Bayes-GenisCarolina Soler-Botija
Jan 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mariya MollovaBernhard Kühn
Jan 25, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Wangde DaiRobert A Kloner
Feb 22, 2013·Science Translational Medicine·Sonya B Seif-NaraghiKaren L Christman
Dec 24, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Lauren E KokaiJ Peter Rubin
Jan 18, 2014·Circulation Research·Marc N HirtThomas Eschenhagen
May 14, 2014·International Journal of Cardiology·Cristina Prat-VidalAntoni Bayes-Genis
Jul 25, 2015·Stem Cell Research & Therapy·Carolina Gálvez-MontónAntoni Bayes-Genis
Oct 28, 2015·Circulation Research·Jacques P GuyetteHarald C Ott

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Citations

Jun 13, 2020·Frontiers in Bioengineering and Biotechnology·Marta Mazzola, Elisa Di Pasquale
Oct 29, 2017·Stem Cell Research & Therapy·Santiago RouraAntoni Bayes-Genis
Mar 7, 2020·European Journal of Pharmacology·Ziwei LiuXiaohui Zhou
Jun 3, 2021·Npj Regenerative Medicine·Miguel F TenreiroMargarida Serra
Oct 2, 2021·Nature Biomedical Engineering·Leyu WangXiaozhong Qiu

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Methods Mentioned

BETA
coronary
biopsies
SMA
light microscopy
xenograft

Software Mentioned

Image
Pro Plus
Image J
SPSS

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