PMID: 3757152Jan 1, 1986Paper

A cellular analysis of long-term haematopoietic damage in mice after repeated treatment with cyclophosphamide

Cancer Chemotherapy and Pharmacology
G MolineuxN G Testa

Abstract

Following repeated treatment of mice with cyclophosphamide (5 X 200 mg/kg) it was found that slight, but significant, residual marrow damage persisted for at least half the lifespan of the animals. This long-term damage occurred despite preferential sparing of those multi-potential haematopoietic cells (CFU-S) that had a high self-renewal capacity after each step of the multistep regimen and despite a smaller CFU-S kill after each successive dose. The damage was characterized by low mean numbers of CFU-S and stromal colony-forming cells (CFU-F) which were around 70% of control values. Examination of individual animals revealed that the majority had slightly subnormal numbers of CFU-S and CFU-F, with only a few suffering a more severe injury, including 8% of mice with clinical hypoplasia or myelodysplasia.

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Citations

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·C TwelvesA Goldstone
Jul 25, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jae-Lyun LeeCheolwon Suh
Jan 1, 1995·Leukemia & Lymphoma·C AulW Schneider
May 26, 2011·Journal of Translational Medicine·Ioannis AlagkiozidisGeorge Coukos
Oct 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M TubianaE Frindel
Mar 9, 2004·Bone Marrow Transplantation·C D FordF B Petersen

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