PMID: 2896960May 21, 1988Paper

A cellular basis for the primary long Q-T syndromes

Lancet
D Attwell, J A Lee

Abstract

In several syndromes sudden death is associated with a long Q-T interval on the electrocardiogram. Current treatment is aimed at correcting a notional imbalance of cardiac sympathetic drive. Although this approach can be effective, the primary disorder may be a defect in the cellular mechanism that alters the length of the ventricular action potential, and hence the Q-T interval, in response to a change of heart rate. Such defects may be underdiagnosed because the long Q-T syndromes are defined simply in terms of a prolonged Q-T interval, without consideration of the fact that susceptibility to arrhythmias is likely to be due, not to a lengthened Q-T per se, but to an absence or alteration of the normal Q-T shortening in response to an increase of heart rate. People susceptible to R-on-T related arrhythmias could be identified by measurement of the dependence of the Q-T interval on heart rate and how quickly the Q-T interval adapts to a change in rate.

Citations

Mar 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A BoschK Schärer
Apr 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y Adu-GyamfiS K Sanyal
Sep 1, 1990·Journal of the American College of Cardiology·R G WeintraubJ L Wilkinson
Aug 1, 1992·Journal of the American College of Cardiology·G M Vincent
Jun 1, 1994·Journal of the American College of Cardiology·W ZarebaW J Hall
Nov 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R PadriniR Antolini
Feb 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·J B ChambersG Jackson
Jan 1, 1993·Fundamental & Clinical Pharmacology·F CharpentierH Le Marec
Jul 1, 1994·Clinical Physiology·B Wohlfart, O Pahlm
Jun 1, 1992·Pacing and Clinical Electrophysiology : PACE·M A Habbab, N el-Sherif
Jul 1, 1992·Pacing and Clinical Electrophysiology : PACE·C M BellamyR G Charles
Jul 7, 1999·Pacing and Clinical Electrophysiology : PACE·T Emori, T Ohe
Jan 27, 1992·Annals of the New York Academy of Sciences·M ManoachD Varon
Sep 1, 1991·British Heart Journal·N J LinkerD E Ward
Nov 4, 2000·Journal of Cardiovascular Electrophysiology·P KowallikM Meesmann
Dec 1, 1993·IEEE Transactions on Bio-medical Engineering·M MerriA J Moss
Aug 24, 1995·Nature·P B BennettA L George
Jun 23, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Kazuhiro TakahashiHitoshi Ganaha
Nov 26, 2008·Progress in Biophysics and Molecular Biology·Mark J PerrinAdam P Hill
Jul 19, 2005·Progress in Biophysics and Molecular Biology·Chantal E Conrath, Tobias Opthof

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