PMID: 13575671Sep 1, 1958Paper

A cellular basis of immunity in experimental Brucella infection

The Journal of Experimental Medicine
J J HOLLAND, M J PICKETT

Abstract

Brucella suis, Brucella abortus, and Brucella melitensis were shown by microscopic and cultural procedures to multiply extensively within normal rat, mouse, and guinea pig monocytes maintained in vitro in cell cultures for 3 days. Intracellular growth of brucellae had no observable toxic effects on most monocytes, although many of the cells became completely engorged with brucellae within 3 days. Non-smooth brucellae and strain 19 multiplied slowly within normal monocytes. In contrast, "immune" monocytes) i.e. those derived from animals previously infected with smooth brucellae, greatly restricted the intracellular growth of smooth and non-smooth brucellae and strain 19. Growth of smooth Brucella, within either normal or "immune" monocytes, was not influenced by addition of Brucella antiserum to the culture medium. Desensitization of immunized guinea pigs did not diminish the refractory state of their monocytes. Cellular resistance did not develop when animals were vaccinated with heat-killed brucellae, though these animals did produce agglutinating antibody. Similarly, vaccination of animals with living, rough B. suis failed to induce a refractory state in their monocytes, even though the vaccinated animals developed delayed h...Continue Reading

References

Nov 1, 1956·The Journal of Infectious Diseases·D T BERMANE M SIMON
Dec 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·J J HOLLAND, M J PICKETT
Feb 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·W BRAUNW R STINEBRING
May 1, 1955·The Journal of Infectious Diseases·E M SIMOND T BERMAN

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Citations

May 15, 1979·Medical Microbiology and Immunology·I N Egwu, W C Eveland
Jan 1, 1971·Folia Microbiologica·N B Kamzolkina, N S Zacharova
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·E Schneider, M Dy
Jan 1, 1987·Annales De L'Institut Pasteur. Microbiology·M Plommet
Mar 13, 1965·Nature·D Sulitzeanu
Aug 1, 1960·The Journal of Experimental Medicine·G D SnellS J Parker
Oct 17, 2007·Infection and Immunity·Elisabeth BillardAntoine Gross
Mar 8, 2016·International Journal of Medical Microbiology : IJMM·Jens JacobMartin Mielke
Feb 26, 2011·Immunological Reviews·Anna MartirosyanJean-Pierre Gorvel
Nov 21, 1960·Annals of the New York Academy of Sciences·J B WILSON, B L DASINGER
Nov 21, 1960·Annals of the New York Academy of Sciences·E L NELSON, R S BERK
Mar 1, 1977·Bacteriological Reviews·L Barksdale, K S Kim
Feb 1, 1971·Infection and Immunity·D J Ralston, S S Elberg
Mar 1, 1960·Bacteriological Reviews·S S ELBERG
Sep 1, 1962·Journal of Bacteriology·K SAITOD USHIBA
Jul 1, 1983·Infection and Immunity·M Plommet, A M Plommet
Dec 1, 1974·Bacteriological Reviews·F M Collins
Oct 1, 1965·Journal of Bacteriology·P J Baker, J B Wilson
Dec 1, 1963·Bacteriological Reviews·C R JENKIN, D ROWLEY
Dec 1, 1959·Journal of Bacteriology·M Richardson

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