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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

Science

Jul 14, 2001

György HutvágnerPhillip D Zamore

Abstract

The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA in...read more

Mentioned in this Paper

RNA Conformation
RNA Interference Pathway
Northern Blot
Biochemical Pathway
DICER1 wt Allele
Let-7
Developmental Timing
RNA Precursor
Poly(A) Tail
Gene Expression Regulation, Developmental
964
1
2
Paper Details
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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

Science

Jul 14, 2001

György HutvágnerPhillip D Zamore

PMID: 11452083

DOI: 10.1126/science.1062961

Abstract

The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA in...read more

Mentioned in this Paper

RNA Conformation
RNA Interference Pathway
Northern Blot
Biochemical Pathway
DICER1 wt Allele
Let-7
Developmental Timing
RNA Precursor
Poly(A) Tail
Gene Expression Regulation, Developmental
964
1
2
Paper Details
References
  • References
  • Citations1282
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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