PMID: 11514022Aug 22, 2001Paper

A central link between angiotensinergic and cholinergic systems; role of vasopressin

Peptides
N I BuyukcoskunK Ozluk

Abstract

Participation of central cholinergic system in the effects of intracerebroventricular (i.c.v.) injection of angiotensin II (Ang II) on blood pressure and heart rate was studied in conscious, freely moving rats. Ang II dose-dependently increased blood pressure and decreased heart rate. Both atropine and mecamylamine (i.c.v.) pretreatments prevented the cardiovascular effects of Ang II. Pretreatment with a vasopressin V1 antagonist also prevented the cardiovascular responses to Ang II. Our data suggest that the central pressor effect of Ang II is mediated in part by central acetylcholine via both muscarinic and nicotinic receptors, and vasopressin participates in this effect through V1 receptors.

References

Feb 22, 1978·Pflügers Archiv : European journal of physiology·D Haack, J Möhring
May 1, 1992·Acta Physiologica Scandinavica·H HjelmqvistM Rundgren
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E ColombariJ V Menani
Aug 1, 1988·Journal of Hypertension·M I Phillips, B Kimura
Nov 1, 1983·Neuropharmacology·P NicolettaA P Caputi
Jul 23, 1993·Regulatory Peptides·B BunnemannD Ganten
Apr 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A SaadW A Saad

❮ Previous
Next ❯

Citations

Jun 13, 2006·Brain Research·Marcin UfnalEwa Szczepańska-Sadowska
Jun 4, 2008·Clinical and Experimental Pharmacology & Physiology·Naciye Isbil-BuyukcoskunIsmail H Ulus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.