A central master driver of psychosocial stress responses in the rat

Science
Naoya KataokaKazuhiro Nakamura

Abstract

The mechanism by which psychological stress elicits various physiological responses is unknown. We discovered a central master neural pathway in rats that drives autonomic and behavioral stress responses by connecting the corticolimbic stress circuits to the hypothalamus. Psychosocial stress signals from emotion-related forebrain regions activated a VGLUT1-positive glutamatergic pathway from the dorsal peduncular cortex and dorsal tenia tecta (DP/DTT), an unexplored prefrontal cortical area, to the dorsomedial hypothalamus (DMH), a hypothalamic autonomic center. Genetic ablation and optogenetics revealed that the DP/DTT→DMH pathway drives thermogenic, hyperthermic, and cardiovascular sympathetic responses to psychosocial stress without contributing to basal homeostasis. This pathway also mediates avoidance behavior from psychosocial stressors. Given the variety of stress responses driven by the DP/DTT→DMH pathway, the DP/DTT can be a potential target for treating psychosomatic disorders.

References

Jul 5, 2001·Physiology & Behavior·K Björkqvist
Jun 11, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kazuhiro NakamuraTakeshi Kaneko
Jun 19, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J HoriuchiR A L Dampney
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Y Ootsuka, R M McAllen
Dec 22, 2005·The European Journal of Neuroscience·Yoshiko NakamuraShaun F Morrison
Apr 4, 2006·Autonomic Neuroscience : Basic & Clinical·Joseph A DiMiccoDmitry V Zaretsky
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip L Johnson, Anantha Shekhar
Aug 26, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kazuhiro Nakamura, Shaun F Morrison
Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip L JohnsonAnantha Shekhar
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mutsumi Tanaka, Robin M McAllen
Dec 18, 2007·Nature Neuroscience·Kazuhiro Nakamura, Shaun F Morrison
Mar 4, 2008·Stress : the International Journal on the Biology of Stress·Youichirou OotsukaEugene Nalivaiko
Aug 30, 2008·Autonomic Neuroscience : Basic & Clinical·R A L DampneyL M McDowall
Sep 3, 2010·The Journal of Physiology·Wei ZhangTomoyuki Kuwaki
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kazuhiro Nakamura
Jun 14, 2013·Cell and Tissue Research·Iulia Toth, Inga D Neumann
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ada C Felix-Ortiz, Kay M Tye
Nov 5, 2015·Nature·Avishek AdhikariKarl Deisseroth
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Takakazu Oka
Nov 9, 2018·ENeuro·Mark LaubachSamantha R White
Dec 24, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shane B JohnsonJason J Radley

❮ Previous
Next ❯

Citations

Apr 4, 2020·Nature Reviews. Neuroscience·Natasha Bray
Apr 2, 2020·Nature·Dayu Lin
Dec 23, 2020·Trends in Cognitive Sciences·Alan S Cowen, Dacher Keltner
Nov 20, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Mitchell G MiglisSrikanth Muppidi
Jan 31, 2021·Animal : an International Journal of Animal Bioscience·Lorelle A BarrettDominique Blache
Apr 15, 2021·International Immunology·Masaki Ueno
May 13, 2021·Seminars in Cell & Developmental Biology·Janardhan P BhattaraiMinghong Ma
Jun 12, 2021·Neuropharmacology·Gavin N PetrieMatthew N Hill
Jul 6, 2021·Frontiers in Psychology·Qing LiuWenjuan Zhang
Jun 22, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Fernanda Ribeiro MarinsMarco Antônio Peliky Fontes
Nov 4, 2021·Nature Reviews. Neuroscience·Kazuhiro NakamuraNaoya Kataoka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.