A centrally acting antihypertensive agent (R28935) not mediated via central alpha-adrenoreceptors.

European Journal of Pharmacology
L Finch

Abstract

Intraventricular administration (i.c.v.) of R28935 (25 mug) produced a marked fall in blood pressure without any bradycardia in conscious renal hypertensive cats. This hypotensive effect was not antagonised by central administration of tolazoline (200 mug i.c.v.) or phentolamine (200 mug). However, these doses of alpha-adrenoreceptor blocking agents did antagonise the centrally mediated hypotensive actions of clonidine (20 mug i.c.v.) or alpha-methyl-dopa (1 mg i.c.v.). Infusions of R28935 in the perfused artery preparation did not modify the basal perfusion pressures or modify the vasoconstrictor actions of noradrenaline or 5-hydroxytryptamine. The results suggest that R28935, an analogue of pimozide, exerts a central hypotensive effect not mediated via central alpha-adrenoreceptors, and does not have any peripheral sympathomimetic action.

References

Aug 1, 1975·British Journal of Pharmacology·L FinchP Hicks
Mar 1, 1975·European Journal of Pharmacology·H A Struyker Boudier, A D Bekers
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·G Haeusler, L Finch
May 1, 1974·Clinical and Experimental Pharmacology & Physiology·L M Wing, J P Chalmers
Jun 1, 1968·The Journal of Pharmacy and Pharmacology·M Henning, P A van Zwieten
Mar 1, 1973·European Journal of Pharmacology·L Finch, G Haeusler
Feb 1, 1973·British Journal of Pharmacology·L Finch, G Haeusler
Apr 1, 1971·European Journal of Pharmacology·A Barnett, J W Fiore
Jan 1, 1971·European Journal of Pharmacology·P Bolme, K Fuxe

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Citations

Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·A J LoonenI V Wijngaarden
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·N E AndénG Trolin
Feb 1, 1980·European Journal of Pharmacology·P B Timmermans, P A Van Zwieten
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·D G Taylor, M J Antonaccio
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Xue-Qing LiCollen M Masimirembwa
Jan 1, 1980·British Journal of Clinical Pharmacology·P A van Zwieten
Dec 1, 1982·Biochemical Pharmacology·P B TimmermansP A van Zwieten

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