A ceramic-based anticancer drug delivery system to treat breast cancer.

Journal of Materials Science. Materials in Medicine
A El-GhannamDidier Dréau

Abstract

Drug delivery systems offer the advantage of sustained targeted release with minimal side effect. In the present study, the therapeutic efficacy of a porous silica-calcium phosphate nanocomposite (SCPC) as a new delivery system for 5-Fluorouracil (5-FU) was evaluated in vitro and in vivo. In vitro studies showed that two formulations; SCPC50/5-FU and SCPC75/5-FU hybrids were very cytotoxic for 4T1 mammary tumor cells. In contrast, control SCPCs without drug did not show any measurable toxic effect. Release kinetics studies showed that SCPC75/5-FU hybrid provided a burst release of 5-FU in the first 24 h followed by a sustained release of a therapeutic dose (30.7 microg/day) of the drug for up to 32 days. Moreover, subcutaneous implantation of SCPC75/5-FU hybrid disk in an immunocompetent murine model of breast cancer stopped 4T1 tumor growth. Blood analyses showed comparable concentrations of Ca, P and Si in animals implanted with or without SCPC75 disks. These results strongly suggest that SCPC/5-FU hybrids can provide an effective treatment for solid tumors with minimal side effects.

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Citations

Nov 4, 2010·Journal of Materials Science. Materials in Medicine·H GautierJ M Bouler
Apr 6, 2012·Journal of Materials Science. Materials in Medicine·Saravanabhavan Shanmuga Sundar, Dharmalingam Sangeetha
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Nov 4, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Angel ManchónEnrique Lopez Cabarcos
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Jun 13, 2015·Journal of Biomaterials Applications·Ching-Li TsengTzu-Piao Tang
Jun 27, 2019·Pharmaceutics·Mostafa MabroukDiganta B Das

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