A change in the isoforms of human chorionic gonadotropin occurs around the 13th week of gestation

The Journal of Clinical Endocrinology and Metabolism
L WideC Rasmussen

Abstract

hCG exhibits a considerable heterogeneity in blood during pregnancy. The overall charge of the isoforms of hCG has been shown to be more negative in the early than in the latter part of pregnancy. The present study analyzes the change in median charge and the charge heterogeneity as pregnancy progresses. The hCG activity in sera from 76 women from weeks 6-43 of gestation was measured with a noncompetitive time-resolved sandwich fluoroimmunoassay. The median charge and degree of charge heterogeneity of the isoforms of hCG in each serum was determined by electrophoresis in 0.10% agarose suspension. Median charge was expressed as median electrophoretic mobility. Electrophoresis with a high resolution revealed that the number of isoforms of hCG in a serum specimen from week 36 of gestation was 20-30. A change in median charge was found to occur at a limited time period of gestation, around the 13th week. All 16 sera from weeks 6-10 had isoforms of hCG with a more negative median charge than that of hCG in 21 sera from weeks 16-43 of gestation. The change in charge was accompanied by an increased degree of charge heterogeneity. There was a significant (P < 0.01) correlation between median mobility and the concentration of hCG during...Continue Reading

Citations

Sep 27, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·P BergerUNKNOWN Members of the ISOBM TD-7 Workshop on hCG and Related Molecules
Sep 21, 2017·International Journal of Molecular Sciences·Veronica SaraisPaola Vigano'
May 25, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Johan A SteierOle L Myking

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