PMID: 3756162Oct 9, 1986Paper

A change in the lipid fluidity of the porcine intestinal brush-border membranes by lipid peroxidation. Studies using pyrene and fluorescent stearic acid derivatives

Biochimica Et Biophysica Acta
T OhyashikiT Mohri

Abstract

The effect of lipid peroxidation on the lipid fluidity of porcine intestinal brush-border membranes was examined by measuring the rotational mobility and the accessibility to fluorescence quenchers (CH3COOT1, CuSO4 and KI) of pyrene or n-(9-anthroyloxy)stearic acid (n = 2 or 12) in the membranes. The harmonic mean of the rotational relaxation times of pyrene increased and the rate constants, kq, of the quenching reaction of pyrene and 2-(9-anthroyloxy)stearic acid incorporated in the membrane lipids decreased upon lipid peroxidation, indicating reduction of the lipid fluidity of the membranes by lipid peroxidation. In addition, the kq value of the reaction of 2-(9-anthroyloxy)stearic acid in the membranes with Cu2+ decreased in proportion to the amount of the products of lipid peroxidation. On the other hand, the kq value of the reaction of 12-(9-anthroyloxy)stearic acid with Cu2+ or I- was unaffected by lipid peroxidation. Based on these results, a localized change in the lipid fluidity of the membranes in association with lipid peroxidation has been discussed.

References

Jan 1, 1978·Physiological Reviews·M TadaY Tonomura
Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Dec 15, 1978·Biochimica Et Biophysica Acta·M Shinitzky, Y Barenholz
Jan 1, 1976·Annual Review of Pharmacology and Toxicology·G L Plaa, H Witschi
May 28, 1985·Biochimica Et Biophysica Acta·C Rice-EvansP Hochstein
Jan 9, 1985·Biochimica Et Biophysica Acta·J SunamotoH Kondo
May 21, 1982·Biochimica Et Biophysica Acta·T OhyashikiT Mohri
Jun 1, 1981·Biochemical and Biophysical Research Communications·C Rice-Evans, P Hochstein

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Citations

Jan 1, 1993·Pharmacology & Therapeutics·J Quiroga, J Prieto
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C P LeBel, S C Bondy
Jan 1, 1988·Free Radical Biology & Medicine·J M Patel, E R Block
Nov 1, 2003·The International Journal of Biochemistry & Cell Biology·V M BhorS Sivakami
Nov 28, 2002·Alimentary Pharmacology & Therapeutics·L Kruidenier, H W Verspaget
Dec 1, 1994·Journal of Toxicology and Environmental Health·S H ParkR A Schatz
Mar 1, 1995·Journal of Toxicology and Environmental Health·M P Mingeot-LeclercqA Schanck
Mar 5, 2011·Journal of Clinical Biochemistry and Nutrition·Satoshi TanidaTakashi Joh
Sep 25, 2012·World Journal of Gastroenterology : WJG·Umbreen AhmedPhillip S Oates
Feb 1, 1991·Archives of Biochemistry and Biophysics·T OhyashikiK Matsui
Oct 1, 1991·Experimental and Molecular Pathology·A TangorraE Bertoli
Oct 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D ErbaşM Ulküer
Jul 28, 2006·Hearing Research·Guang-Di Chen, Hong-Bo Zhao
Dec 13, 2005·Journal of Ethnopharmacology·Kavithalakshmi S NatarajanE R B Shanmugasundaram
Jul 1, 1991·Archives of Biochemistry and Biophysics·T OhyashikiK Matsui
Mar 3, 2004·Biochimica Et Biophysica Acta·Namakkal Surappan RajasekaranHalagowder Devaraj
Jun 6, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kenjiro KogaKanji Takada
Aug 1, 1990·International Journal of Radiation Biology·M Rybczynska
Jul 26, 2005·Biochemistry. Biokhimii︠a︡·C F CanakçiV Canakçi
May 1, 1991·International Journal of Radiation Biology·W LeykoG Bartosz
Sep 17, 2020·Journal of Ethnopharmacology·Firdaus KausarPervaiz Ahmad
Jul 1, 1987·Chemistry and Physics of Lipids·C Richter

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