A change of heart: oxidative stress in governing muscle function?

Biophysics Reviews
Martin Breitkreuz, Nazha Hamdani

Abstract

Redox/cysteine modification of proteins that regulate calcium cycling can affect contraction in striated muscles. Understanding the nature of these modifications would present the possibility of enhancing cardiac function through reversible cysteine modification of proteins, with potential therapeutic value in heart failure with diastolic dysfunction. Both heart failure and muscular dystrophy are characterized by abnormal redox balance and nitrosative stress. Recent evidence supports the synergistic role of oxidative stress and inflammation in the progression of heart failure with preserved ejection fraction, in concert with endothelial dysfunction and impaired nitric oxide-cyclic guanosine monophosphate-protein kinase G signalling via modification of the giant protein titin. Although antioxidant therapeutics in heart failure with diastolic dysfunction have no marked beneficial effects on the outcome of patients, it, however, remains critical to the understanding of the complex interactions of oxidative/nitrosative stress with pro-inflammatory mechanisms, metabolic dysfunction, and the redox modification of proteins characteristic of heart failure. These may highlight novel approaches to therapeutic strategies for heart failure...Continue Reading

References

Aug 1, 1992·Circulation Research·F BennardiniM Chiesi
Sep 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J L SkibbaJ H Kalbfleisch
May 1, 1991·British Heart Journal·J J BelchM Chopra
Jan 1, 1987·Free Radical Research Communications·R H BurdonC Rice-Evans
Jan 1, 1989·Chemico-biological Interactions·M Comporti
Mar 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M J Cline, R I Lehrer
May 1, 1996·Circulation Research·R BarbatoF Di Lisa
Mar 1, 1996·Diabetes Care·D GiuglianoG Paolisso
Dec 20, 1996·Neuroreport·J W HaycockD Mantle
May 29, 1998·Journal of Molecular and Cellular Cardiology·A A KnowltonD L Mann
Aug 1, 1998·Circulation Research·I J Benjamin, D R McMillan
Dec 16, 1998·The Journal of Physiology·P Krippeit-DrewsG Drews
Jan 8, 1999·Journal of the Neurological Sciences·M H DisatnikT A Rando
Apr 30, 1999·Physiological Reviews·R Bolli, E Marbán
Oct 26, 1999·Cell Structure and Function·K YoshidaS Ohno
Nov 24, 1999·Biochimica Et Biophysica Acta·A V TkatchenkoC A Dechesne
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·S DukanT Nyström
Sep 12, 2000·Current Hypertension Reports·R M Touyz
Dec 21, 2000·American Journal of Physiology. Cell Physiology·D A SiwikW S Colucci
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F H AndradeH Westerblad
Mar 14, 2001·Neuroscience·M Y AksenovW R Markesbery
Mar 17, 2001·Medicine and Science in Sports and Exercise·M B Reid
Aug 30, 2001·Experimental Gerontology·J A Thomas, R J Mallis
Oct 31, 2001·The Journal of Biological Chemistry·J WangP B Chock

❮ Previous
Next ❯

Citations

Aug 5, 2017·JCI Insight·Tsukasa ShimauchiMotohiro Nishida
Mar 7, 2020·Frontiers in Cardiovascular Medicine·Nina Kaludercic, Fabio Di Lisa
Jan 13, 2018·Molecular and Cellular Biochemistry·Appalaraju JaggupilliPrashen Chelikani
Sep 15, 2020·Journal of Cellular Biochemistry·Shishir UpadhyayMonisha Dhiman
Dec 8, 2020·Oxidative Medicine and Cellular Longevity·Kai WangLuyu Zhou
May 22, 2021·Free Radical Biology & Medicine·David Weissman, Christoph Maack

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.