A changing etiologic scenario in liver transplantation for hepatocellular carcinoma in a multicenter cohort study from Latin America

Clinics and Research in Hepatology and Gastroenterology
Federico PiñeroLatin American Liver Research, Education, Awareness Network (LALREAN)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of hepatocellular carcinoma (HCC) and liver transplantation (LT). Our study focused on changing trends of liver related HCC etiologies during the last years in Latin America. From a cohort of 2761 consecutive adult LT patients between 2005 and 2012 in 17 different centers, 435 with HCC were included. Different periods including years 2005-2006, 2007-2008, 2009-2010 and 2011-2012 were considered. Etiology of liver disease was confirmed in the explant. Participating LT centers per country included 2 from Brazil (n=191), 5 transplant programs from Argentina (n=98), 2 from Colombia (n=65), 4 from Chile (n=49), 2 from Mexico (n=12), and 1 from Peru (n=11) and Uruguay (n=9). Chronic hepatitis C infection was the leading cause of HCC in the overall cohort (37%), followed by HBV (25%) and alcoholic liver disease (17%). NAFLD and cryptogenic cirrhosis accounted for 6% and 7%, respectively. While HCV decreased from 48% in 2005-06 to 26% in 2011-12, NAFLD increased from 1.8% to 12.8% during the same period, accounting for the third cause of HCC. This represented a 6-fold increase in NAFLD-HCC, whereas HCV had a 2-fold decrease. Patients with NAFLD were older, had lower pre-L...Continue Reading

Citations

Feb 6, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jianghua ZhouHongliang Li
Oct 22, 2019·Arquivos De Gastroenterologia·Edison Roberto Parise
Oct 13, 2018·World Journal of Gastroenterology : WJG·Federico PiñeroMarcelo Silva
Mar 8, 2021·Revista de gastroenterología de México·K P Rojas-PintorL E Muñoz-Espinosa
May 10, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lorenzo A OrciChristian Toso
Jul 10, 2021·World Journal of Gastroenterology : WJG·Federico Piñero, Leonardo Gomes da Fonseca
Aug 14, 2021·Revista De Gastroenterología De México·K P Rojas-PintorL E Muñoz-Espinosa

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