A chemical biology approach reveals an opposite action between thermospermine and auxin in xylem development in Arabidopsis thaliana

Plant & Cell Physiology
Kaori YoshimotoHiroyasu Motose

Abstract

Thermospermine, a structural isomer of spermine, is produced through the action of ACAULIS5 (ACL5) and suppresses xylem differentiation in Arabidopsis thaliana. To elucidate the molecular basis of the function of thermospermine, we screened chemical libraries for compounds that can modulate xylem differentiation in the acl5 mutant, which is deficient in thermospermine and shows a severe dwarf phenotype associated with excessive proliferation of xylem vessels. We found that the isooctyl ester of a synthetic auxin, 2,4-D, remarkably enhanced xylem vessel differentiation in acl5 seedlings. 2,4-D, 2,4-D analogs and IAA analogs, including 4-chloro IAA (4-Cl-IAA) and IAA ethyl ester, also enhanced xylem vessel formation, while IAA alone had little or no obvious effect on xylem differentiation. These effects of auxin analogs were observed only in the acl5 mutant but not in the wild type, and were suppressed by the anti-auxin, p-chlorophenoxyisobutyric acid (PCIB) and α-(phenyl ethyl-2-one)-IAA (PEO-IAA), and also by thermospermine. Furthermore, the suppressor of acaulis51-d (sac51-d) mutation, which causes SAC51 overexpression in the absence of thermospermine and suppresses the dwarf phenotype of acl5, also suppressed the effect of au...Continue Reading

References

Aug 1, 1991·Current Opinion in Genetics & Development·P W Ingham
Feb 12, 1998·The Plant Journal : for Cell and Molecular Biology·Y HanzawaY Komeda
Jun 1, 2000·Bioscience, Biotechnology, and Biochemistry·M Katayama
Mar 20, 2003·Plant Physiology·Jim MattssonThomas Berleth
Oct 4, 2003·Plant Physiology·Yutaka OonoHirofumi Uchimiya
Mar 8, 2005·Annals of Botany·Andrew W Woodward, Bonnie Bartel
Aug 17, 2005·Genes & Development·Minoru KuboTaku Demura
Apr 19, 2006·Genes & Development·Enrico ScarpellaThomas Berleth
Nov 3, 2006·Phytochemistry·Markus GershaterRobert Edwards
Jan 16, 2007·The Plant Journal : for Cell and Molecular Biology·Carol L WenzelJim Mattsson
May 24, 2007·The Journal of Biological Chemistry·Markus C GershaterRobert Edwards
Jun 8, 2007·Development·Danielle P VidaurreThomas Berleth
Oct 2, 2007·Current Opinion in Plant Biology·Hiroo FukudaShinichiro Sawa
Feb 13, 2008·The Plant Journal : for Cell and Molecular Biology·Hiroyasu MotoseYuichiro Watanabe
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ken-Ichiro HayashiHiroshi Nozaki
May 1, 2008·The Plant Journal : for Cell and Molecular Biology·Masatoshi YamaguchiTaku Demura
Jul 26, 2008·Molecular Biology and Evolution·Eugenio G MinguetMiguel A Blázquez
Aug 2, 2008·Plant & Cell Physiology·Jun-ichi KakehiTaku Takahashi
Aug 13, 2008·The Plant Journal : for Cell and Molecular Biology·Akihiro ImaiTaku Takahashi
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuki HirakawaHiroo Fukuda
Sep 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sigal Savaldi-GoldsteinJoanne Chory
Oct 8, 2008·Annual Review of Cell and Developmental Biology·Jürgen Kleine-Vehn, Jirí Friml
Mar 20, 2009·Plant Physiology·Jocelyn A OzgaAruna D Wickramarathna
Jul 28, 2009·Development·Jan Petrásek, Jirí Friml
Jul 29, 2009·Chembiochem : a European Journal of Chemical Biology·Naoyuki KusakaHiroshi Nozaki
Aug 1, 2009·The International Journal of Biochemistry & Cell Biology·Kazuei Igarashi, Keiko Kashiwagi

❮ Previous
Next ❯

Citations

Mar 28, 2013·Plant Cell Reports·Ana Milhinhos, Célia M Miguel
Feb 18, 2016·Scientific Reports·Kaori YoshimotoTaku Takahashi
Mar 7, 2013·Journal of Integrative Plant Biology·William J LucasPradeep Kachroo
Apr 30, 2014·Molecular Plant·Simona BaimaGiorgio Morelli
Jul 4, 2012·Plant Signaling & Behavior·Kaori YoshimotoHiroyasu Motose
Oct 18, 2012·Plant Signaling & Behavior·Yoshiteru NoutoshiKen Shirasu
Mar 29, 2014·Frontiers in Plant Science·Wurina TongTaku Takahashi
Jul 9, 2016·Plant & Cell Physiology·Qingqing CaiTaku Takahashi
Sep 12, 2017·Annual Review of Genetics·Raili RuonalaYkä Helariutta
Jul 2, 2019·The Plant Journal : for Cell and Molecular Biology·Shiori ShinoharaTaku Takahashi
May 24, 2019·Frontiers in Plant Science·Soichi IshitsukaTaku Takahashi
May 8, 2013·The Plant Journal : for Cell and Molecular Biology·Ana MilhinhosCélia M Miguel
Feb 16, 2021·Frontiers in Plant Science·Johnatan VilasboaArthur Germano Fett-Neto
Jun 8, 2014·Plant Physiology·Dong Wook KimTomonobu Kusano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.