PMID: 3059055Oct 1, 1988Paper

A chemical classification of nonsteroidal antagonists of sex-steroid hormone action

Journal of Steroid Biochemistry
J F Miquel, J Gilbert

Abstract

A highly varied collection of nonsteroids have been reported over the last forty years as being able to exert an antihormonal action versus steroid hormones in vivo. This diversity is partly explained by the manifold molecular targets of these compounds which may be either enzymes or receptors (leading to inhibition of steroid production and action respectively) and by the different possible levels of interference within feedback loops between the central nervous system, pituitary, gonads and other peripheral organs. The present chapter is a chemist's classification of some of these structures often in the absence of detailed biochemical data. Nonsteroid antiestrogens (and estrogens) most often share a common feature with diethylstilbestrol and consequently the effects of structural modifications on biological activities can be studied in a rational manner. This is not the case for non-steroidal antiandrogens that we have only been able to classify into conventional chemical groups. Nor have any true lead compounds nor well-defined chemical classes been identified for nonsteroid antiprogestogens. This is however the only hormonal class where natural products play an important role.

References

Jun 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N DevleeschouwerJ C Heuson
Oct 15, 1979·American Journal of Obstetrics and Gynecology·B M LandgrenE Diczfalusy
Jul 1, 1975·Journal of Steroid Biochemistry·D E Bu'Lock, C M Jackson
Jan 1, 1979·Fertility and Sterility·L C Huppert
Jun 1, 1979·Biochemical Society Transactions·R NeriA Watnick
Nov 1, 1977·The Journal of Endocrinology·V C JordanG Prestwich
Aug 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R I Nicholson, M P Golder
Jul 11, 1975·Journal of Medicinal Chemistry·A RichardsonD E Holtkamp
Jul 1, 1975·Journal of Medicinal Chemistry·P KoleN Anand
Jun 1, 1975·Journal of Steroid Biochemistry·R O Neri, E A Peets
Mar 1, 1986·Contraception·G GallianiA Assandri
Jun 1, 1987·The Journal of Endocrinology·B J FurrH Tucker
Jan 1, 1985·Chemotherapy·L C FordR J DeLange
Sep 1, 1985·Environmental Health Perspectives·V C JordanM E Lieberman
Jun 1, 1985·Journal of Medicinal Chemistry·R M KanojiaD Hahn
Oct 1, 1985·Journal of Medicinal Chemistry·A B FosterN Devleeschouwer
Oct 1, 1985·Journal of Medicinal Chemistry·R KurodaO T Leung
Dec 1, 1985·Journal of Medicinal Chemistry·H Morales-AlanisC Tournemine
Dec 1, 1985·Journal of Medicinal Chemistry·M R SchneiderH Schönenberger
Nov 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M FromsonS Bramah
Dec 1, 1974·Journal of Medicinal Chemistry·I H HallC Piantadosi
Dec 1, 1974·Journal of Medicinal Chemistry·F P PalopoliA Richardson
Nov 1, 1972·Journal of Medicinal Chemistry·R R CrenshawM E Bierwagen
Apr 1, 1973·Archives of Environmental Health·J W LloydM G Mawhinney
Jun 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·R J Orts, B Benson
May 1, 1973·Journal of Medicinal Chemistry·J W Scott, A Boris
Nov 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M FromsonS Bramah

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Citations

Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A VerstuyfR Bouillon
Sep 29, 1989·Biochemical and Biophysical Research Communications·E BignonY Nishizuka
Dec 1, 1993·Critical Reviews in Oncology/hematology·S K ChanderY A Luqmani
Feb 14, 1990·Biochemical and Biophysical Research Communications·E BignonY Nishizuka

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