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A chemical switch for inhibitor-sensitive alleles of any protein kinase

Nature

Oct 3, 2000

A BishopKevan M Shokat

Abstract

Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts to assign specific signalling roles to individual kinases. Here we describe a chemical geneti...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Protein Kinase Inhibitors
Mitogen-Activated Protein Kinases
Transcription, Genetic
Gene Products, Protein
Tertiary Protein Structure
Homologous Sequences, Amino Acid
Indole Alkaloids
Gene Expression
Carbazoles
3
753
1
Paper Details
References
  • References23
  • Citations425
12345...

A chemical switch for inhibitor-sensitive alleles of any protein kinase

Nature

Oct 3, 2000

A BishopKevan M Shokat

PMID: 11014197

DOI: 10.1038/35030148

Abstract

Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts to assign specific signalling roles to individual kinases. Here we describe a chemical geneti...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Protein Kinase Inhibitors
Mitogen-Activated Protein Kinases
Transcription, Genetic
Gene Products, Protein
Tertiary Protein Structure
Homologous Sequences, Amino Acid
Indole Alkaloids
Gene Expression
Carbazoles
3
753
1
Paper Details
References
  • References23
  • Citations425
12345...
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