A chemical tool box defines mitotic and interphase roles for Mps1 kinase.

The Journal of Cell Biology
Weijie Lan, Don W Cleveland

Abstract

In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase and mitotic inhibitors of Cdc20, and correction of faulty microtubule attachments.

References

Jan 15, 2004·Journal of the American Chemical Society·Shuibing ChenSheng Ding
Jul 9, 2004·Developmental Cell·Patrick MeraldiPeter K Sorger
Dec 29, 2004·Current Biology : CB·Harold A Fisk, Mark Winey
Jan 26, 2005·Current Biology : CB·Michele H JonesMark Winey
Oct 1, 2005·Nature Reviews. Cancer·Geert J P L KopsDon W Cleveland
Sep 5, 2006·Current Biology : CB·Anne Lide KnowltonP Todd Stukenberg
Apr 12, 2007·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Edward D Salmon
Dec 7, 2007·Current Biology : CB·Jean-François MaureTomoyuki U Tanaka
Mar 18, 2008·Molecular Cell·Julien EspeutAriane Abrieu
May 17, 2008·Molecular Cancer Therapeutics·Anna Morena D'AliseRiccardo Cortese
Jun 11, 2008·The Journal of Cell Biology·Anthony TigheStephen Taylor
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Aniek JanssenRené H Medema
Apr 13, 2010·Nature Chemical Biology·Nicholas KwiatkowskiNathanael S Gray
Jul 14, 2010·The Journal of Cell Biology·Laura HewittStephen S Taylor

❮ Previous
Next ❯

Citations

Feb 1, 2012·Chromosoma·Bungo Akiyoshi, Sue Biggins
Jun 19, 2013·Chromosoma·Anna-Leena Salmela, Marko J Kallio
Nov 3, 2011·The Journal of Biological Chemistry·Chang LiuHai Rao
Aug 14, 2013·Journal of the National Cancer Institute·Bakhos A TannousThomas Würdinger
Dec 12, 2012·Open Biology·Richard BaylissSharon Yeoh
Feb 15, 2013·Journal of Virology·Wondimagegnehu M TeferiDavid H Evans
Sep 12, 2012·BMC Complementary and Alternative Medicine·Yi-Jen HsiehChih-Jui Chang
Apr 16, 2011·Cell Division·Amanda N Pike, Harold A Fisk
Oct 11, 2012·PloS One·Eduardo Alves Gamosa de OliveiraMarco Antônio Lopes Cruz
Apr 10, 2012·Annual Review of Biochemistry·Xuedong Liu, Mark Winey
Feb 15, 2011·Expert Opinion on Therapeutic Targets·Riccardo Colombo, Jürgen Moll
Oct 13, 2010·The Journal of Cell Biology·Nannette JellumaGeert J P L Kops
Apr 10, 2013·The Journal of Cell Biology·Wilco NijenhuisGeert J P L Kops
Aug 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Zhen DouXuebiao Yao
Mar 8, 2016·Current Opinion in Cell Biology·Banafsheh Etemad, Geert J P L Kops
May 16, 2013·Journal of Chemical Information and Modeling·Sarah R LangdonJulian Blagg
Mar 10, 2016·The Journal of Cell Biology·Mayumi IsokaneJan Ellenberg
Sep 15, 2015·Oncogene·A KochR H Medema
Aug 18, 2012·Developmental Cell·Mathijs VleugelGeert J P L Kops
Mar 17, 2015·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Lénaïg DéfachellesRoger E Karess
May 29, 2012·Bioorganic & Medicinal Chemistry Letters·D Vijay KumarRobert O Carlson
Apr 24, 2012·Current Biology : CB·Nitobe LondonSue Biggins
Sep 16, 2016·PLoS Genetics·M Kasim DirilPhilipp Kaldis
Aug 13, 2013·Cell Death and Differentiation·M JemaàG Kroemer
Aug 16, 2018·Annual Review of Pharmacology and Toxicology·Masanori KawakamiEthan Dmitrovsky
Feb 21, 2019·Molecular Biology of the Cell·Hongdan YangJungseog Kang
Dec 18, 2015·Oncotarget·Agnese RestucciaWei Dai
Dec 8, 2015·Oncotarget·Mohamed JemaàAriane Abrieu
Jul 21, 2017·The Journal of Biological Chemistry·Yoshitaka HirumaAnastassis Perrakis
Jun 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan ChenJin-Gui Zheng
Sep 27, 2018·Scientific Reports·M S RashidW R Taylor

❮ Previous
Next ❯

Methods Mentioned

BETA
Gene knockout
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.