A Chemo-poroelastic Analysis of Mechanically Induced Fluid and Solute Transport in an Osteonal Cortical Bone.

Annals of Biomedical Engineering
Z-H JinM L Peterson

Abstract

It is well known that transport of nutrients and wastes as solute in bone fluid plays an important role in bone remodeling and damage healing. This work presents a chemo-poroelastic model for fluid and solute transport in the lacunar-canalicular network of an osteonal cortical bone under cyclic axial mechanical loading or vascular pressure. Analytical solutions are obtained for the pore fluid pressure, and fluid and solute velocities. Numerical results for fluid and calcium transport indicate that under a cyclic stress of 20 MPa, the magnitudes of the fluid and calcium velocities increase with an increase in the loading frequency for the frequency range considered (≤ 3 Hz) and peak at the inner boundary. The peak magnitude of calcium velocity reaches 18.9 μm/s for an osteon with a permeability of 1.5 × 10-19 m2 under a 3 Hz loading frequency. The magnitude of calcium velocity under a vascular pressure of 50 mmHg is found to be two orders of magnitude smaller than that under the mechanical load. These results have the potential to be important in understanding fundamental aspects of cortical bone remodeling as transport characteristics of calcium and other nutrients at the osteon scale influence bone metabolism.

References

Jul 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D M NunamakerM T Provost
Dec 1, 1987·Cell Calcium·B S Donahue, R F Abercrombie
Mar 27, 1999·Journal of Biomechanics·S C Cowin
Jan 6, 2001·Annals of Biomedical Engineering·L WangS P Fritton
Feb 16, 2005·Annals of Biomedical Engineering·S GururajaR S Lakes
Feb 16, 2005·Annals of Biomedical Engineering·Felix W Wehrli, María A Fernández-Seara
Jan 11, 2007·The Journal of Experimental Biology·Justine J RobilliardAlan M Wilson
Jun 6, 2008·Journal of Biomechanics·Grant C GouletRonald F Zernicke
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Stephen C CowinMohammed Benalla
Jan 15, 2010·Annual Review of Fluid Mechanics·Susannah P Fritton, Sheldon Weinbaum
Aug 18, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christopher PriceLiyun Wang
Oct 31, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bin WangLiyun Wang
Nov 24, 2012·Journal of Biomechanics·Luis CardosoStephen C Cowin
May 22, 2013·Biomechanics and Modeling in Mechanobiology·Andre F Pereira, Sandra J Shefelbine
Feb 18, 2014·Equine Veterinary Journal·S MartigR C Whitton
Feb 11, 2015·Journal of Biomechanics·Stephen C Cowin, Luis Cardoso
Jan 20, 2018·Current Osteoporosis Reports·Liyun Wang
Mar 15, 2019·International Journal for Numerical Methods in Biomedical Engineering·Ganesharajah GanadhiepanLihai Zhang
Mar 17, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Smriti GhimireLihai Zhang

❮ Previous
Next ❯

Citations

Jun 13, 2021·Bone·José Manuel García-AznarMaría José Gómez-Benito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved