PMID: 9419363Feb 21, 1998Paper

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America
M D GunnL T Williams

Abstract

Preferential homing of naive lymphocytes to secondary lymphoid organs is thought to involve the action of chemokines, yet no chemokine has been shown to have either the expression pattern or the activities required to mediate this process. Here we show that a chemokine represented in the EST database, secondary lymphoid-tissue chemokine (SLC), is expressed in the high endothelial venules of lymph nodes and Peyer's patches, in the T cell areas of spleen, lymph nodes, and Peyer's patches, and in the lymphatic endothelium of multiple organs. SLC is a highly efficacious chemoattractant for lymphocytes with preferential activity toward naive T cells. Moreover, SLC induces firm adhesion of naive T lymphocytes via beta2 integrin binding to the counter receptor, intercellular adhesion molecule-1, a necessary step for lymphocyte recruitment. SLC is the first chemokine demonstrated to have the characteristics required to mediate homing of lymphocytes to secondary lymphoid organs. In addition, the expression of SLC in lymphatic endothelium suggests that the migration of lymphocytes from tissues into efferent lymphatics may be an active process mediated by this molecule.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M C HuB Holzmann
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Oct 1, 1994·Current Opinion in Cell Biology·S D Rosen, C R Bertozzi
Sep 1, 1995·Immunology Today·J P Girard, T A Springer
Aug 1, 1995·The Journal of Experimental Medicine·J G Cyster, C C Goodnow
Jul 1, 1993·The Journal of Experimental Medicine·R F Bargatze, E C Butcher
Jan 1, 1993·Advances in Immunology·C R Mackay
Apr 5, 1996·Science·E C Butcher, L J Picker
Jun 1, 1996·Immunology Today·J Westermann, R Pabst
Sep 1, 1996·The Journal of Experimental Medicine·C C BleulT A Springer
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
Apr 1, 1997·Current Biology : CB·C C Goodnow, J G Cyster
Jun 27, 1949·Annals of the New York Academy of Sciences·E J KEPLER

❮ Previous
Next ❯

Citations

Jun 8, 1999·European Journal of Immunology·F SallustoA Lanzavecchia
Dec 18, 2001·European Journal of Immunology·G BardiP Loetscher
Apr 9, 2008·Inflammatory Bowel Diseases·Bertus EksteenDavid H Adams
Feb 10, 2000·Springer Seminars in Immunopathology·U SyrbeA Hamann
Aug 21, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Joseph J SkitzkiSharon S Evans
May 16, 2007·Cancer Immunology, Immunotherapy : CII·Gang XueWenlin Huang
Mar 17, 2006·Cell and Tissue Research·Chikako OdakaToshio Suda
Jul 24, 2008·Cell and Tissue Research·Giorgia Jurisic, Michael Detmar
Nov 10, 2009·Cell and Tissue Research·Kazuhiko ShimizuTaichi Ezaki
Jul 6, 2013·International Journal of Clinical Oncology·Koshi MimoriKeishi Sugimachi
Sep 25, 2007·Clinical & Experimental Metastasis·Adit Ben-Baruch
Oct 1, 2013·Molecular Biology Reports·Rilun LiChunmin Liang
Dec 19, 2003·Current Allergy and Asthma Reports·Melissa K Callahan, Richard M Ransohoff
May 7, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nazita YousefiehRichard P Ciavarra
Aug 7, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Taotao LiYulong He
Feb 27, 2004·Biochimica Et Biophysica Acta·Yulong HeKari Alitalo
Mar 25, 2004·Trends in Immunology·Enrico CrivellatoDomenico Ribatti
Jun 15, 2004·Journal of Dermatological Science·Satoshi Hirakawa, Michael Detmar
Jan 8, 2004·Microvascular Research·Shin-ichiro KuroshimaNobuo Inoue
Mar 6, 2004·Seminars in Immunology·Lars OhlReinhold Förster
Mar 6, 2004·Seminars in Immunology·Michael Dee Gunn
Mar 6, 2004·Seminars in Immunology·Wolfgang Weninger, Ulrich H von Andrian
Mar 26, 2004·Tissue & Cell·Shin-ichiro KuroshimaNobuo Inoue
Sep 6, 2002·Biochemical Pharmacology·Catherine van MontfransSander van Deventer
Jan 22, 2003·Journal of Immunological Methods·Carlo Laudanna, Gabriela Constantin
Apr 26, 2003·Mechanisms of Ageing and Development·I GomezB Grubeck-Loebenstein
Dec 1, 1999·Developmental and Comparative Immunology·K M Lam
May 10, 2003·Brain Research. Brain Research Reviews·Paul R WalkerPierre Yves Dietrich
Sep 11, 1999·Immunology Letters·K ChristophersonR Hromas
Nov 26, 2002·Journal of Neuroimmunology·Xiuju JiangDoina Ganea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.