A child with eosinophilia, Loeffler endocarditis, and acute lymphoblastic leukemia.

Pediatric Cardiology
Matthew D FilesStephen M Langley

Abstract

We present an 8-year-old male with Loeffler endocarditis and acute lymphoblastic leukemia with hypereosinophilia (ALL/Eo) who initially presented with a 3-month history of peripheral eosinophilia thought to be due to visceral larval migrans. Despite treatment for Toxocara, his leukocytosis persisted and he developed mitral valve insufficiency and congestive heart failure. Myocardial biopsy revealed fibrosis and thrombus formation indicative of Loeffler endocarditis, and a peripheral smear showed pre-B-cell acute lymphoid leukemia. This unique case highlights a rare, yet serious sequella of prolonged eosinophilia.

References

May 1, 1973·The Australian and New Zealand Journal of Surgery·J L Taw
May 20, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F MoraesC R Moraes
Jul 15, 2006·Leukemia & Lymphoma·S RezkP M Miron

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Citations

Jun 6, 2012·BMJ Case Reports·Mehrnaz Asadi GharabaghiRamezanali Sharaifian
Mar 28, 2012·Seminars in Hematology·Florence RoufosseLaurence de Leval
Nov 17, 2015·Acta Tropica·Esther KuenzliJohannes Blum
Jul 23, 2013·The American Journal of Case Reports·Azim RezamandNariman Nezami
Jun 6, 2018·International Journal of Environmental Research and Public Health·Valentina FerruzziSusanna Esposito
Oct 31, 2020·Journal of Pediatric Hematology/oncology·Anissa LahfafaBénédicte Brichard

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