PMID: 9543297May 16, 1998Paper

A childhood asthma death in a clinical trial: potential indicators of risk

The European Respiratory Journal
J O WarnerJ A Warner

Abstract

A 9 yr old girl with a history of eczema and asthma was admitted to our specialist asthma service and recruited into a trial designed to investigate systemic as well as therapeutic benefits of inhaled corticosteroids. Eight months after referral the patient died from an acute asthma attack. This childhood asthma death during an inhaled steroid trial has facilitated identification of risk factors. Despite good clinical response to inhaled corticosteroids, the patient was distinguishable from the other patients by: increased variability of the morning and evening peak flow rates; increased reactivity, though not sensitivity, to histamine; and an unprecedented rise in serum soluble interleukin-2 receptor levels immediately after commencing inhaled steroids. The immunological basis for corticosteroid resistance and immunohistochemical studies on postmortem specimens from asthma deaths suggest that T-cell activation markers may be indicators of the fatality prone asthmatic.

Citations

Jul 25, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J O Warner
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·J B CloughJ O Warner
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J O WarnerP Pohunek
Dec 17, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ramesh J KurukulaaratchyS Hasan Arshad
Oct 8, 1999·Chronobiology International·E Haus, M H Smolensky

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