A chimeric 18L1-45RG1 virus-like particle vaccine cross-protects against oncogenic alpha-7 human papillomavirus types

PloS One
Bettina HuberReinhard Kirnbauer

Abstract

Persistent infection with oncogenic human papillomaviruses (HPV) types causes all cervical and a subset of other anogenital and oropharyngeal carcinomas. Four high-risk (hr) mucosal types HPV16, 18, 45, or 59 cause almost all cervical adenocarcinomas (AC), a subset of cervical cancer (CxC). Although the incidence of cervical squamous cell carcinoma (SCC) has dramatically decreased following introduction of Papanicolaou (PAP) screening, the proportion of AC has relatively increased. Cervical SCC arise mainly from the ectocervix, whereas AC originate primarily from the endocervical canal, which is less accessible to obtain viable PAP smears. Licensed (bivalent and quadrivalent) HPV vaccines comprise virus-like particles (VLP) of the most important hr HPV16 and 18, self-assembled from the major capsid protein L1. Due to mainly type-restricted efficacy, both vaccines do not target 13 additional hr mucosal types causing 30% of CxC. The papillomavirus genus alpha species 7 (α7) includes a group of hr types of which HPV18, 45, 59 are proportionally overrepresented in cervical AC and only partially (HPV18) targeted by current vaccines. To target these types, we generated a chimeric vaccine antigen that consists of a cross-neutralizing ...Continue Reading

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Citations

Jan 20, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Karin L LeeNicole F Steinmetz
Nov 28, 2016·Virus Research·Christina SchellenbacherReinhard Kirnbauer
Nov 22, 2017·PeerJ·Hui Kian OngKok Lian Ho
Mar 23, 2017·Biological Chemistry·Somayeh Pouyanfard, Martin Müller
Dec 28, 2019·Viruses·Rashi YadavEbenezer Tumban
Apr 4, 2021·Journal of Clinical Medicine·Bettina HuberReinhard Kirnbauer
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lorena Zapata-CuellarAbel Gutiérrez-Ortega

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Datasets Mentioned

BETA
AY262282

Methods Mentioned

BETA
FCS
transmission electron microscopy
electrophoresis
ELISA
Assay
bioluminescence

Software Mentioned

Living image
Graph Pad Prism
GeneArt

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