PMID: 9188099Mar 1, 1997Paper

A chimeric serine/threonine kinase receptor system reveals the potential of multiple type II receptors to cooperate with transforming growth factor-beta type I receptor

Molecular Biology of the Cell
M MuramatsuK Arai

Abstract

Receptor-type serine/threonine kinases (RSKs) have been organized into two distinct classes known as types I and II on the basis of sequence similarity. However, experiments have shown ligand specificities in the two classes and as a result type I and type II receptors can often bind to a common ligand. The transforming growth factor-beta- (TGF-beta) specific receptors represent such a case, where both type I and II receptors (T beta RI and T beta RII) are observed. Of additional interest is the observation that heteromeric associations of type I and II receptors can also enable signaling. To further elucidate the function of various RSKs, the extracellular domains of both alpha and beta chains from human granulocyte-macrophage colony-stimulating factor receptors were linked to transmembrane cytoplasmic domains of RSKs. Chimeric receptors of human granulocyte-macrophage receptor (hGMR) alpha with T beta RI and hGMR beta with T beta RII were expressed in murine pre-B cell-derived Ba/F3 cells. These chimeras formed heteromeric complexes, transmitted TGF-beta signals, and were down-modulated in response to human granulocyte-macrophage colony-stimulating factor. However, experiments utilizing these chimeric receptors in different c...Continue Reading

References

Apr 15, 1992·Biochemical and Biophysical Research Communications·C J DonaldsonW W Vale
Dec 1, 1992·The Journal of Cell Biology·M B Sporn, A B Roberts
Jan 1, 1990·Annual Review of Biochemistry·K I AraiT Yokota
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K HayashidaA Miyajima
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·B L RosenzweigK Miyazono
Nov 21, 1994·FEBS Letters·A SuzukiN Ueno
Jul 1, 1994·The Journal of Cell Biology·Y I HenisH F Lodish
Aug 4, 1994·Nature·J L WranaJ Massagué
Sep 1, 1994·Molecular and Cellular Biology·B B KoenigR A Grant
Feb 15, 1994·Biochemical and Biophysical Research Communications·T TomodaK Arai
Feb 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·W W HeP K Donahoe
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson

❮ Previous
Next ❯

Citations

Jun 23, 2001·Molecular and Cellular Endocrinology·N JossoL Gouédard
Jul 8, 2000·Trends in Cell Biology·E B Leof
Aug 28, 1998·Cytokine & Growth Factor Reviews·M KawabataK Miyazono
Jun 8, 2010·American Journal of Respiratory Cell and Molecular Biology·Rabih HalwaniQutayba Hamid
Jun 17, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kozo NinomiyaMitsuhiro Yokoyama
Dec 4, 2015·PLoS Computational Biology·Sridevi NagarajaAlexander Y Mitrophanov
Nov 26, 2002·The Journal of Biological Chemistry·Susumu ItohPeter ten Dijke
Jun 7, 2002·Genes & Development·Elaine S SetoThomas E Lloyd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.