A chitosan-hyaluronic acid hydrogel scaffold for periodontal tissue engineering

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Diego G MirandaKerstin Gritsch

Abstract

The current challenge in treating periodontitis is regenerating the periodontium. This motivates tissue-engineering researchers to develop scaffolds as artificial matrices that give mechanical support for osteoblasts, cementoblasts, gingival and periodontal ligament fibroblast cells. In this study, modified hyaluronic acid (HA) and chitosan (CS) were employed to create a hybrid CS-HA hydrogel scaffold for periodontal regeneration. CS, HA, and CS-HA scaffolds were obtained by freeze-drying technique, resulting in porous structures suitable for use in tissue engineering. Scaffolds were submitted to gamma and UV-sterilization without significant morphology changes. The ATR-FTIR spectra of CS-HA hydrogels showed peaks at 377 cm-1 , 1566 cm-1 , and 1614 cm-1 , representing secondary amide, primary amine, and carboxyl acid respectively, and it was also observed the emergence of peaks at 886 cm-1 , which probably represents the Schiff base formed in the case of hybrid CS-HA hydrogels. The scaffolds presented a high rate of PBS uptake, reaching values higher than 95%. Thermal degradation of HA scaffolds was around 225°C and CS was around 285°C. The ATR-FTIR spectra and swelling degree were slightly disturbed mainly after gamma steriliz...Continue Reading

References

May 1, 1993·Journal of Periodontology·H Birkedal-Hansen
Dec 9, 1993·Clinical Materials·I P MatthewsA H Samuel
Sep 18, 2002·The Journal of Cell Biology·Paola SpessottoValter Gattei
Feb 12, 2004·Journal of Biomaterials Science. Polymer Edition·J D BumgardnerJ L Ong
Aug 19, 2007·Biomaterials·Jindrich Kopecek
Feb 29, 2008·Journal of Biomedical Materials Research. Part a·Betsy M ChesnuttJoel D Bumgardner
Sep 4, 2008·Journal of Periodontology·William V Giannobile
Feb 21, 2009·Journal of Oral Rehabilitation·E L SchellerD H Kohn
Sep 8, 2009·Acta Biomaterialia·A MichiardiV Migonney
Jul 21, 2010·Journal of Clinical Periodontology·Daniel S ThomaChristoph H F Hämmerle
Jan 25, 2011·International Journal of Biological Macromolecules·Fan ZhangJinwu Wang
Jan 27, 2011·Biochemical and Biophysical Research Communications·Michinao KawanoTatsuji Nishihara
Mar 12, 2011·Advanced Materials·Jason A Burdick, Glenn D Prestwich
Mar 30, 2011·Journal of Applied Biomaterials & Biomechanics : JABB·Xiaoying LüWei Cui
Sep 14, 2011·Biotechnology Progress·Hai-Hua SunFa-Ming Chen
Oct 21, 2011·Clinical Oral Investigations·Karim M Fawzy El-SayedMona S Darhous
Dec 6, 2011·Journal of Applied Biomaterials & Biomechanics : JABB·Elisa BattistellaLia Rimondini
Feb 14, 2013·International Journal of Biological Macromolecules·Timothy E L DouglasSander C G Leeuwenburgh
Apr 12, 2013·Periodontology 2000·Jørgen Slots
May 23, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maqsood AhmedAlexander M Seifalian
Jun 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Liming BianJason A Burdick
Jul 3, 2013·North American Journal of Medical Sciences·Parveen Dahiya, Reet Kamal
Sep 17, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maqsood AhmedAlexander M Seifalian
Oct 29, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Cristina Martínez-Ramos, Myriam Lebourg
Feb 3, 2015·Journal of Clinical Periodontology·Kristina BertlAndreas Stavropoulos

❮ Previous
Next ❯

Citations

Mar 17, 2017·ACS Applied Materials & Interfaces·H RammalH Kerdjoudj
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yujie ChenHezhou Liu
Jul 19, 2020·Biomimetics·Muhammad Sohail ZafarNaresh Kumar
Aug 29, 2020·Tissue Engineering. Part a·Adél HinsenkampIstván Hornyák
Aug 5, 2017·Materials·Shehriar HusainSaad B Qasim
May 18, 2020·International Journal of Molecular Sciences·Håvard Jostein HaugenJanne Elin Reseland
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Xiaoni LiQiuzi Wang
Jan 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jirapat NamkaewSupansa Yodmuang
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yaqi Lyu, Helena S Azevedo
Dec 16, 2020·Polymers·Marwa M S AbbassKarim M Fawzy El-Sayed
Feb 23, 2020·Bioactive Materials·Md Minhajul IslamTaslim Ur Rashid
Apr 4, 2021·Polymers·Jonathan David HinchliffeIpsita Roy
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola d'AvanzoMassimo Fresta
Jun 10, 2021·Journal of Biomaterials Applications·Thaís Vieira de SouzaArnaldo R Santos
Jul 2, 2021·International Journal of Oral Science·Sevda Pouraghaei SevariAlireza Moshaverinia
Jul 11, 2021·Journal of Biomedical Materials Research. Part a·José Carlos Viana RibeiroVilma Lima
Oct 9, 2019·International Journal of Biological Macromolecules·Janaína Oliveira GonçalvesLuiz Antonio de Almeida Pinto
Mar 20, 2018·Biomacromolecules·Ozge Karabiyik AcarGamze Torun Kose
Jan 13, 2018·ACS Applied Materials & Interfaces·Xiaomin WangDeling Kong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Hilla Barkay-Olami, Meital Zilberman
Journal of Biomedical Materials Research. Part a
Tatiana C Gamboa-MartínezGloria Gallego-Ferrer
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Márcia A RebeloMarco V Chaud
© 2021 Meta ULC. All rights reserved