PMID: 9166408Jun 2, 1997Paper

A Chlamydomonas homologue of the putative murine t complex distorter Tctex-2 is an outer arm dynein light chain

The Journal of Cell Biology
R S Patel-KingS M King

Abstract

Molecular analysis of a 19,000-Mr protein from the Chlamydomonas flagellum reveals that it is homologous to the t complex-encoded protein Tctex-2, which is a candidate for one of the distorter products that cause the extreme transmission ratio distortion (meiotic drive) of the murine t complex. The 19,000-Mr protein is extracted from the axoneme with 0.6 M NaCl and comigrates with the outer dynein arm in sucrose density gradients. This protein also is specifically missing in axonemes prepared from a mutant that does not assemble the outer arm. These data raise the possibility that Tctex-2 is a sperm flagellar dynein component. Combined with the recent identification of Tctex-1 (another distorter candidate) as a light chain of cytoplasmic dynein, these results lead to a biochemical model for how differential defects in spermiogenesis that result in the phenomenon of meiotic drive might be generated in wild-type vs t-bearing sperm.

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Citations

Apr 29, 1998·Cell Motility and the Cytoskeleton·I Milisav
Oct 24, 1998·Cell Motility and the Cytoskeleton·K K PfisterS M King
Jun 23, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L R Fraser, K Dudley
Mar 24, 2004·Journal of Structural Biology·Miho Sakato, Stephen M King
May 29, 2000·Trends in Genetics : TIG·J Schimenti
Sep 3, 1998·Molecular Biology of the Cell·M E Fowkes, D R Mitchell
Oct 1, 2005·Molecular Biology of the Cell·Linda M DiBellaStephen M King
Aug 3, 2012·Molecular Biology of the Cell·Panteleimon RompolasStephen M King
Jan 28, 2006·PLoS Genetics·K Kevin PfisterElizabeth M C Fisher
Sep 26, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Sajid RashidJuergen Neesen
Dec 3, 2014·Computational Biology and Chemistry·Zahida ParveenSajid Rashid
Jan 31, 2004·Cell Motility and the Cytoskeleton·Karina NikulinaStephen M King
Sep 28, 2007·Traffic·Bill Wickstead, Keith Gull
Sep 30, 2006·Cell Motility and the Cytoskeleton·David E WilkesDavid J Asai
Nov 18, 2005·Journal of Molecular Biology·Jikui SongJohn L Markley
Oct 16, 2003·Biochemical and Biophysical Research Communications·Kazuo Ogawa, Kazuo Inaba
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Nov 18, 2003·Annual Review of Genetics·Mary F Lyon
Mar 21, 2000·Biochimica Et Biophysica Acta·S M King
Sep 12, 2018·Biology of Reproduction·Maximiliano TourmenteEduardo R S Roldan
Aug 3, 2017·Cold Spring Harbor Perspectives in Biology·Rasagnya ViswanadhaMary E Porter
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Sep 11, 2014·Journal of Cell Science·David AsanteDavid J Stephens
Mar 6, 1999·Biochemical and Biophysical Research Communications·K InabaK Ogawa

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