A chloride channel widely expressed in epithelial and non-epithelial cells

Nature
A ThiemannT J Jentsch

Abstract

Chloride channels have several functions, including the regulation of cell volume, stabilizing membrane potential, signal transduction and transepithelial transport. The plasma membrane Cl- channels already cloned belong to different structural classes: ligand-gated channels, voltage-gated channels, and possibly transporters of the ATP-binding-cassette type (if the cystic fibrosis transmembrane regulator is a Cl- channel). The importance of chloride channels is illustrated by the phenotypes that can result from their malfunction: cystic fibrosis, in which transepithelial transport is impaired, and myotonia, in which ClC-1, the principal skeletal muscle Cl- channel, is defective. Here we report the properties of ClC-2, a new member of the voltage-gated Cl- channel family. Its sequence is approximately 50% identical to either the Torpedo electroplax Cl- channel, ClC-0 (ref. 8), or the rat muscle Cl- channel, ClC-1 (ref. 9). Isolated initially from rat heart and brain, it is also expressed in pancreas, lung and liver, for example, and in pure cell lines of fibroblastic, neuronal, and epithelial origin, including tissues and cells affected by cystic fibrosis. Expression in Xenopus oocytes induces Cl- currents that activate slowly u...Continue Reading

References

Oct 1, 1991·The American Journal of Physiology·K M KreuselU Hegel
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R A SchoumacherT A Rado
Jul 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M J Welsh
Apr 1, 1991·The American Journal of Physiology·R T Worrell, R A Frizzell
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C L WardJ J Wine
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M P Anderson, M J Welsh
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C K BauerT J Jentsch
Apr 1, 1991·The American Journal of Physiology·K StrangeS R Gullans
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W H Cliff, R A Frizzell
Apr 1, 1987·Physiological Reviews·A H Bretag
Jun 1, 1989·The American Journal of Physiology·R T WorrellR A Frizzell
Mar 1, 1984·The American Journal of Physiology·S GrinsteinE W Gelfand
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle

❮ Previous
Next ❯

Citations

Jan 27, 1998·Microscopy Research and Technique·W Zhang, G M Roomans
Jul 1, 1996·The Journal of Experimental Zoology·C H GelbandJ R Martens
Sep 1, 1999·Journal of Neuroscience Research·R E IsaacksM D Norenberg
Jan 3, 2001·Microscopy Research and Technique·T SpeakeP D Brown
May 1, 1993·Pflügers Archiv : European journal of physiology·G T McEwanN L Simmons
Oct 1, 1994·Pflügers Archiv : European journal of physiology·P KomwatanaD I Cook
Feb 1, 1995·Journal of Bioenergetics and Biomembranes·C F Higgins
Oct 1, 1996·Molecular Neurobiology·S Basavappa, J C Ellory
Nov 30, 2005·Cellular and Molecular Life Sciences : CMLS·M SuzukiT Iwamoto
Mar 22, 2006·The Journal of Membrane Biology·G UgarteJ Bacigalupo
Apr 23, 2010·The Journal of Membrane Biology·Akihiro InagakiToru Ishikawa
Aug 5, 2009·Pediatric Surgery International·Andreas Ringman UgglaBjörn Frenckner
May 24, 2005·Pflügers Archiv : European journal of physiology·Christophe DurantonFlorian Lang
Oct 15, 2008·Pflügers Archiv : European journal of physiology·Vanessa PlansThomas J Jentsch
Jan 6, 2010·Pflügers Archiv : European journal of physiology·Leigh WellhauserChristine E Bear
Mar 31, 2010·Pflügers Archiv : European journal of physiology·Aristea S Galanopoulou
May 2, 2013·Pflügers Archiv : European journal of physiology·Gabriel StöltingChristoph Fahlke
Aug 1, 1996·Pflügers Archiv : European journal of physiology·J P WinpennyM A Gray
Mar 6, 2007·Journal of the Association for Research in Otolaryngology : JARO·Chunyan QuBradley A Schulte
Aug 7, 2009·Digestive Diseases and Sciences·Misa MizumoriJonathan D Kaunitz
Sep 1, 1994·The International Journal of Biochemistry·A M Silvestro, R H Ashley
Jun 25, 1993·Biochimica Et Biophysica Acta·T AbeK Abe
Aug 1, 1994·Current Opinion in Cell Biology·T J Jentsch
Jun 1, 1993·Current Opinion in Neurobiology·T J Jentsch
Jan 1, 1993·Trends in Cardiovascular Medicine·M J Ackerman, D E Clapham
Jan 1, 1997·Progress in Biophysics and Molecular Biology·B NiliusG Droogmans
Aug 7, 1998·Brain Research. Developmental Brain Research·G H ClaytonR L Smith
Sep 5, 1998·Brain Research. Developmental Brain Research·G H ClaytonR L Smith
Sep 9, 2000·Biochimica Et Biophysica Acta·M E LoewenG W Forsyth
Jun 6, 1998·Biochimica Et Biophysica Acta·J Eggermont
Oct 1, 1996·General Pharmacology·B NiliusG Droogmans
Jan 1, 1997·Hearing Research·T OshimaT Takasaka
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·B A CookeM Choi
Aug 23, 2003·Molecular and Cellular Neurosciences·Judit K MakaraHelmut Kettenmann
May 28, 2013·Lancet Neurology·Christel DepienneMarjo S van der Knaap

❮ Previous
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