A chloride current component induced by hypertrophy in rat ventricular myocytes

The American Journal of Physiology
J P BénitahW J Lederer

Abstract

The effect of hypertrophy on membrane currents of rat left ventricular myocytes was studied with the whole cell voltage-clamp method. We found that the slope of the total time-independent current density-voltage relationship was increased in hypertrophied cells. No change in the zero-current potential was observed. Surprisingly, the dominant time-independent current, the inward rectifier K+ current (measured as the Ba(2+)-sensitive current density) was unchanged. We therefore investigated the identity of the outwardly rectifying Ba(2+)-resistant current seen in the hypertrophied rat ventricular myocytes but not present in control cells. We found that this current 1) was not carried by monovalent cations, 2) was partially blocked by anthracene-9-carboxylic acid (9-AC), and 3) was sensitive to variations in extracellular Cl concentration. These findings are consistent with the current being carried at least partially by Cl-. The presence of an additional Cl(-)-dependent component in hypertrophied cells is supported by the actions of 9-AC on the measured action potentials (APs). 9-AC had no effect on control cells APs but prolonged hypertrophied cell APs. We conclude that a Cl- current component develops in hypertrophied rat heart...Continue Reading

Citations

Jul 16, 2011·Journal of Pharmacological Sciences·Shintaro YamamotoTakahiro Iwamoto
Apr 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Donglin GuoGan-Xin Yan
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J A WasserstromO M Sejersted
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J MészárosG Hart
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jeremy P DwyerRobert Di Nicolantonio
May 7, 2003·Progress in Biophysics and Molecular Biology·Clive M Baumgarten, Henry F Clemo

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