A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma

Neuro-oncology
Greg D EleyC David James

Abstract

Cumulative information available about the organization of amplified chromosomal regions in human tumors suggests that the amplification repeat units, or amplicons, can be of a simple or complex nature. For the former, amplified regions generally retain their native chromosomal configuration and involve a single amplification target sequence. For complex amplicons, amplified DNAs usually undergo substantial reorganization relative to the normal chromosomal regions from which they evolve, and the regions subject to amplification may contain multiple target sequences. Previous efforts to characterize the 7p11.2 epidermal growth factor receptor ) amplicon in glioblastoma have relied primarily on the use of markers positioned by linkage analysis and/or radiation hybrid mapping, both of which are known to have the potential for being inaccurate when attempting to order loci over relatively short (<1 Mb) chromosomal regions. Due to the limited resolution of genetic maps that have been established through the use of these approaches, we have constructed a 2-Mb bacterial and P1-derived artificial chromosome (BAC-PAC) contig for the EGFR region and have applied markers positioned on its associated physical map to the analysis of 7p11.2 ...Continue Reading

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Citations

Jun 24, 2010·Journal of Molecular Histology·Alexander Baras, Christopher A Moskaluk
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Oct 29, 2021·Frontiers in Cell and Developmental Biology·Runzhi HuangJie Zhang

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