May 5, 2015

A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years

BioRxiv : the Preprint Server for Biology
Hang ZhouKun Tang

Abstract

The spatiotemporal distribution of recent human adaptation is a long standing question. We developed a new coalescent-based method that collectively assigned human genome regions to modes of neutrality or to positive, negative, or balancing selection. Most importantly, the selection times were estimated for all positive selection signals, which ranged over the last half million years, penetrating the emergence of anatomically modern human (AMH). These selection time estimates were further supported by analyses of the genome sequences from three ancient AMHs and the Neanderthals. A series of brain function-related genes were found to carry signals of ancient selective sweeps, which may have defined the evolution of cognitive abilities either before Neanderthal divergence or during the emergence of AMH. Particularly, signals of brain evolution in AMH are strongly related to Alzheimer's disease pathways. In conclusion, this study reports a chronological atlas of natural selection in Human.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Study
Biochemical Pathway
Genome
Genes
Brain
Ability to Perform Cognitive Activity
Alzheimer's Disease
Equilibrium
Adaptation
Brain Function

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Alzheimer's Disease: Microglia (Preprints)

Microglial proliferation and activation, as well as its concentration around amyloid plaques, is a prominent feature of Alzheimer’s disease. Here is the latest research on microglia and Alzheimer’s disease.

Related Papers

PloS One
William E BanksMaria-Fernanda Sánchez-Goñi
Proceedings of the National Academy of Sciences of the United States of America
Jean-Jacques Hublin
BioRxiv : the Preprint Server for Biology
Matthias SteinrückenYun S. Song
© 2020 Meta ULC. All rights reserved