A Ciliary View of the Immunological Synapse

Cells
C Cassioli, Cosima T Baldari

Abstract

The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function. In recent years many ciliogenesis proteins have been observed at extraciliary sites in cells and likely perform cilium-independent functions ranging from regulation of the cytoskeleton to vesicular trafficking. Perhaps the most striking example is the non-ciliated T lymphocyte, in which components of the ciliary machinery are repurposed for the assembly and function of the immunological synapse even in the absence of a primary cilium. Furthermore, the specialization traits described at the immunological synapse are similar to those seen in the primary cilium. Here, we review common regulators and features shared by the immunological synapse and the primary cilium that document the remarkable homology between these structures.

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Citations

Dec 6, 2019·Frontiers in Cell and Developmental Biology·Francesca FinettiCosima T Baldari
Jun 6, 2020·Antioxidants·Ana Martin-HurtadoFrancesc R Garcia-Gonzalo
Jun 4, 2020·Cells·Anton V Burakov, Elena S Nadezhdina
Jan 28, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pieter SchellekensDjalila Mekahli
Jan 30, 2021·EMBO Reports·Tomoharu Kanie, Peter K Jackson
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Mayu HosioEsko Kankuri
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Manami Toriyama, Ken J Ishii
Apr 9, 2021·Frontiers in Cell and Developmental Biology·Francesca FinettiCosima T Baldari
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Noa Beatriz Martín-CófrecesFrancisco Sánchez-Madrid
Apr 16, 2021·Physiological Genomics·Raghad BuqailehWissam A AbouAlaiwi
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Nagaja Capitani, Cosima T Baldari
Jul 24, 2021·Cell Death and Differentiation·Nagaja CapitaniCosima T Baldari
Aug 24, 2021·Journal of Cell Science·Chiara CassioliCosima T Baldari

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Methods Mentioned

BETA
electron microscopy
GTPase
nucleotide exchange
GTPases

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