A Circadian and Cardiac Intraocular Pressure Sensor for Smart Implantable Lens

IEEE Transactions on Biomedical Circuits and Systems
Achille DonidaDiego Barrettino

Abstract

This paper presents a new system to measure the Intraocular Pressure (IOP) with very high accuracy (0.036 mbar) used for monitoring glaucoma. The system not only monitors the daily variation of the IOP (circadian IOP), but also allows to perform an spectral analysis of the pressure signal generated by the heartbeat (cardiac IOP). The system comprises a piezoresistive pressure sensor, an application-specific integrated circuit (ASIC) to read out the sensor data and an external reader installed on customized glasses. The ASIC readout electronics combines chopping modulation with correlated double sampling (CDS) in order to eliminate both the amplifier offset and the chopper ripple at the sampling frequency. In addition, programmable current sources are used to compensate for the atmospheric pressure ( 800-1200 mbar ) and the circadian component (± 7 mbar) thus allowing to read out the very weak cardiac signals (± 1.6 mbar) with a maximum accuracy of 0.036 mbar.

References

Apr 29, 2008·IEEE Transactions on Bio-medical Engineering·Fernando NuñoJosé A Alvarez-Canal
Jun 23, 2009·Survey of Ophthalmology·Steve Y-W LiangDavid Shields
Jul 3, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jorg Draeger
Jun 28, 2012·IEEE Transactions on Bio-medical Engineering·Girish ChitnisBabak Ziaie
Dec 1, 2010·IEEE Transactions on Biomedical Circuits and Systems·Eric Y ChowPedro P Irazoqui
Oct 11, 2013·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Filippo PiffarettiPeter Stegmaier

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