A circadian clock regulates sensitivity to cadmium in Paramecium tetraurelia

Cell Biology and Toxicology
Robert Hinrichsen, Joseph R Tran

Abstract

The heavy metal cadmium is a dangerous environmental toxicant that can be lethal to humans and other organisms. This paper demonstrates that cadmium is lethal to the ciliated protozoan Paramecium tetraurelia and that a circadian clock modulates the sensitivity of the cells to cadmium. Various concentrations of cadmium were shown to increase the number of behavioral responses, decrease the swimming speed of cells, and generate large vacuole formation in cells prior to death. Cells were grown in either 12-h light/12-h dark or constant dark conditions exhibited a toxic response to 500 microM CdCl(2); the sensitivity of the response was found to vary with a 24-h periodicity. Cells were most sensitive to cadmium at circadian time 0 (CT0), while they were least sensitive in the early evening (CT12). This rhythm persisted even when the cells were grown in constant dark. The oscillation in cadmium sensitivity was shown to be temperature-compensated; cells grown at 18 degrees C and 28 degrees C had a similar 24-h oscillation. Finally, phase shifting experiments demonstrated a phase-dependent response to light. These data establish the criteria required for a circadian clock and demonstrate that P. tetraurelia possesses a circadian-influ...Continue Reading

References

Nov 1, 1979·The Journal of Physiology·H Machemer, A Ogura
Jun 1, 1975·Experimental Cell Research·A H ReisnerB S Chandler
Jan 1, 1992·Critical Reviews in Toxicology·M P WaalkesR A Barter
Jan 1, 1988·Trends in Neurosciences·R D Hinrichsen, J E Schultz
Jan 1, 1989·Journal of Biological Rhythms·C H JohnsonJ W Hastings
Jan 1, 1987·Journal of Biological Rhythms·I MiwaT Horie
Jan 1, 1987·Journal of Biological Rhythms·K Hasegawa, A Tanakadate
Apr 5, 1985·Science·W J Hrushesky
Sep 1, 1983·Toxicology·M G Cherian, M Nordberg
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Jan 1, 1995·Advances in Second Messenger and Phosphoprotein Research·R D HinrichsenC Russell
Dec 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·H TokushimaY Nakaoka
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·B A MastersR D Palmiter
Jan 1, 1993·Annual Review of Physiology·C S Pittendrigh
Apr 30, 1996·Toxicology·J Bernal, S Ruvalcaba
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D Bell-PedersenJ C Dunlap
Jun 1, 1997·Toxicology and Applied Pharmacology·D Beyersmann, S Hechtenberg
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D Palmiter
Feb 13, 1999·Cell·J C Dunlap
May 20, 1999·Annual Review of Pharmacology and Toxicology·C D KlaassenS Choudhuri
Jul 7, 1999·Gene·E PiccinniA Kraev
Oct 26, 2000·Reviews on Environmental Health·F PinotB S Polla
Sep 7, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M Watanabe, T Suzuki
Sep 26, 2001·Archives of Toxicology·M BiagioliS Bucci
Oct 24, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·P J Gutiérrez-Yurrita, C Montes
Feb 28, 2002·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Wim WätjenDetmar Beyersmann
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ryuya ShimodaMichael P Waalkes
Jul 25, 2003·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M Einicker-LamasM M Oliveira
Jan 1, 1960·Cold Spring Harbor Symposia on Quantitative Biology·J W HASTINGS
Jan 1, 1960·Cold Spring Harbor Symposia on Quantitative Biology·P J DECOURSEY
Jan 1, 1963·Annual Review of Physiology·J ASCHOFF
Oct 29, 2003·Toxicology·Michael WaisbergDetmar Beyersmann
Oct 27, 2004·Chemico-biological Interactions·Pei-Ming YangLih-Yuan Lin
Nov 10, 2004·Journal of Biological Rhythms·Jay C Dunlap, Jennifer J Loros
May 10, 2005·The Journal of Biological Chemistry·Sreekumar OthumpangatPius Joseph
Sep 9, 2005·Chronobiology International·Hitoshi AndoAkio Fujimura
Nov 23, 2005·Biochemical and Biophysical Research Communications·Eriko MatsubaraAkio Koizumi
Jan 11, 2007·Annual Review of Pharmacology and Toxicology·Francis Levi, Ueli Schibler
Feb 15, 2008·Molecular Biology Reports·Rukhsana Nighat Shuja, Abdul Rauf Shakoori

❮ Previous
Next ❯

Citations

Oct 25, 2014·Sangyō eiseigaku zasshi = Journal of occupational health·Nobuhiko Miura, Katsumi Ohtani
Aug 12, 2015·Proceedings of the National Academy of Sciences of the United States of America·Dawn H NagelSteve A Kay
Nov 29, 2013·The Journal of Toxicological Sciences·Nobuhiko MiuraTatsuya Hasegawa
May 26, 2017·International Journal of Molecular Sciences·Victoria DrechselMartina Höckner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.