PMID: 19912842Feb 1, 1992Paper

A circadian rhythm of somatostatin messenger RNA levels, but not of vasoactive intestinal polypeptide/peptide histidine isoleucine messenger RNA levels in rat suprachiasmatic nucleus

Molecular and Cellular Neurosciences
J TakeuchiS T Inouye

Abstract

Circadian profiles of somatostatin and vasoactive intestinal polypeptide/peptide histidine isoleucine (VIP/PHI) messenger RNA levels in the suprachiasmatic nucleus (SCN) of blinded rats were measured by Northern analysis using synthesized oligonucleotide probes; the SCN is the site of a circadian oscillator. Somatostatin mRNA level in the SCN had a clear circadian rhythm with the peak around the onset of the subjective day and the trough around the onset of the subjective night. This rhythmicity was not observed in the adjacent anterior hypothalamus or the cortex and was thus specific to the SCN. No significant circadian fluctuation was observed in VIP/PHI mRNA levels in the SCN in this experiment. These results indicate the presence of an intrinsic circadian rhythm in the mRNA content of somatostatin, one of the peptides in dorsomedial SCN, and suggest a potential role of the peptide in circadian oscillation and the possible involvement of the transcriptional process in circadian rhythm generation in the SCN.

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Citations

Jan 1, 1994·Neuroscience and Biobehavioral Reviews·O C Ikonomov, A G Stoynev
Jan 1, 1992·Pharmacology & Therapeutics·W J Rietveld
Aug 1, 1994·Neuroscience Research·S T Inouye, S Shibata
Jul 1, 1994·Brain Research. Molecular Brain Research·F R CagampangS T Inouye
Jan 1, 1995·Brain Research Bulletin·M MirmiranN P Bos
Dec 10, 2002·Brain Research·Barbara A M BiemansEddy A Van der Zee
Aug 1, 1997·Brain Research. Molecular Brain Research·B F O'HaraT S Kilduff
Apr 24, 1997·Annals of the New York Academy of Sciences·K L HuhmanH E Albers
Aug 2, 2000·American Journal of Respiratory Cell and Molecular Biology·Y TerasakiN Yamanaka
Feb 17, 2006·Journal of Circadian Rhythms·Vallath Reghunandanan, Rajalaxmy Reghunandanan
Jan 1, 1995·Advances in Neuroimmunology·P J Shiromani, W J Schwartz
Dec 7, 2007·Brain Research Reviews·Mariska J VansteenselJohanna H Meijer
Dec 7, 2018·The European Journal of Neuroscience·Lydia HannouValérie Mongrain
Feb 10, 2006·American Journal of Physiology. Endocrinology and Metabolism·Richard BertramMarc E Freeman
Dec 30, 2015·Journal of Biological Rhythms·Tracey O HermanstyneJeanne M Nerbonne
May 16, 2019·International Journal of Molecular Sciences·Sara HegaziHai-Ying Mary Cheng

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