A circuit for safe diagnostic electrical stimulation of the human brain

Neurological Research
T L BabbP H Crandall

Abstract

An electronic circuit for controlled electrical stimulation of the human brain has been designed to optimize safety in charge transfer from electrodes to brain and to eliminate the likelihood of unwanted currents from the neurostimulator resulting from component failure. The circuit schematics feature the following designs: (1) a highly accurate and versatile rate generator 0.5 p.p.s. to 99 in increments of 0.5 p.p.s., (2) symmetrically-biphasic lead and lag pulses of 100 musec duration, (3) photo-isolated driver amplifiers with accurate waveform, reproduction, (4) true biphasic passive-current regulators driven by an isolated battery supply voltage for switch-selectable currents of 0.25 to 5 ma or variable current regulation, (5) accurate current and voltage waveform monitors that isolate the stimulating electrodes from the monitors, and (6) capacity-coupled outputs to guarantee no net D.C. component at the end of each biphasic pulse. Relay-switching circuits are also shown that allow sequential stimulation and recording from one or several electrodes. This neurostimulator has been in use for over two years without evidence of electrolytic damage at identifiable electrode tips. The utility of simultaneous stimulation of severa...Continue Reading

References

Mar 1, 1976·Electroencephalography and Clinical Neurophysiology·T L Babb, P H Crandall
Sep 1, 1977·Journal of Neurosurgery·W J BrownP H Crandall
Mar 1, 1978·Brain : a Journal of Neurology·E HalgrenP H Crandall
Jan 1, 1977·IEEE Transactions on Bio-medical Engineering·S B Brummer, M J Turner
May 1, 1975·Physiology & Behavior·P E Maxim, F A Spelman
Nov 1, 1971·Electroencephalography and Clinical Neurophysiology·W M Caldwell
Jun 1, 1972·Physiology & Behavior·M J WaynerA Florczyk
May 1, 1970·Journal of Neurosurgery·J T MortimerC Wheeler
May 1, 1961·Journal of Neurosurgery·J M VAN BUREN
Jan 1, 1965·IEEE Transactions on Bio-medical Engineering·V J CAGGIANO

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Citations

Sep 10, 2005·Cerebral Cortex·Xavier PerrotLionel Collet
Jun 24, 2017·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Laure MazzolaJean Isnard
Nov 1, 2011·Brain : a Journal of Neurology·Laure MazzolaFrançois Mauguière
Feb 1, 2011·Pain·Jean IsnardLuis Garcia-Larrea

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