A circuit mechanism for the propagation of waves of muscle contraction in Drosophila

ELife
Akira FushikiAkinao Nose

Abstract

Animals move by adaptively coordinating the sequential activation of muscles. The circuit mechanisms underlying coordinated locomotion are poorly understood. Here, we report on a novel circuit for the propagation of waves of muscle contraction, using the peristaltic locomotion of Drosophila larvae as a model system. We found an intersegmental chain of synaptically connected neurons, alternating excitatory and inhibitory, necessary for wave propagation and active in phase with the wave. The excitatory neurons (A27h) are premotor and necessary only for forward locomotion, and are modulated by stretch receptors and descending inputs. The inhibitory neurons (GDL) are necessary for both forward and backward locomotion, suggestive of different yet coupled central pattern generators, and its inhibition is necessary for wave propagation. The circuit structure and functional imaging indicated that the commands to contract one segment promote the relaxation of the next segment, revealing a mechanism for wave propagation in peristaltic locomotion.

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Citations

Aug 11, 2017·Nature·Katharina EichlerAlbert Cardona
Jul 6, 2019·PLoS Computational Biology·Jane LovelessBarbara Webb
Jun 8, 2019·Journal of Neurogenetics·Youngteak YoonAkinao Nose
Apr 19, 2017·Learning & Memory·Emmanouil PaisiosMichael Schleyer
Jul 31, 2018·Integrative and Comparative Biology·Jane Loveless, Barbara Webb
Feb 15, 2020·Journal of Neurogenetics·Tihana Jovanic
Mar 24, 2020·Nature Neuroscience·Claire EschbachMarta Zlatic
Mar 5, 2020·Developmental Neurobiology·Charalampos MantziarisAnsgar Büschges
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Jan 8, 2020·The Journal of Comparative Neurology·Ernesto HernandezLynne A Oland
Apr 1, 2016·ELife·Laura Masullo, Marco Tripodi
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May 20, 2021·Integrative and Comparative Biology·Jean-Michel MongeauJessleen K Kanwal

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Methods Mentioned

BETA
electron microscopy
transgenic
PCR
light-
microscopy
light microscopy

Software Mentioned

Clampfit
CATMAID
pClamp
Fiji
custom
ImageJ
R
Spike2
MATLAB

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