A circumsporozoite-like protein is present in micronemes of mature blood stages of malaria parasites.

Experimental Parasitology
A H CochraneR S Nussenzweig

Abstract

We demonstrate for the first time the presence of a circumsporozoite (CS)-like protein in invasive blood stages of malaria parasites. Immunogold electron microscopy using antisporozoite monoclonal antibodies localized these antigens in the micronemes of merozoites. Western immunoblot and two-dimensional gel electrophoresis of mature blood stage extracts of Plasmodium falciparum, P. berghei, P. cynomolgi, and P. brasilianum identified polypeptides having the same apparent molecular mass and isoelectric points as the corresponding sporozoite (CS) proteins. The CS-like protein of merozoites is present in relatively minor amounts, compared to the CS protein of sporozoites. Mice with long-term P. berghei blood-induced infections develop antibodies which react with sporozoites.

References

Dec 1, 1988·European Journal of Immunology·P J RomeroF Zavala
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·L N OtooB M Greenwood
Jun 1, 1986·Molecular and Biochemical Parasitology·A MasudaR S Nussenzweig
Jan 1, 1981·Journal of Immunological Methods·A Ferreira, D Eichinger

❮ Previous
Next ❯

Citations

Nov 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·T R BurkotR Spark
Dec 1, 1991·Molecular and Biochemical Parasitology·F M TomleyJ J Kok
Aug 1, 1991·Molecular and Biochemical Parasitology·A AchbarouJ F Dubremetz
Apr 1, 1994·Molecular and Biochemical Parasitology·D A FidockA Asavanich
Jan 20, 2006·International Journal of Medical Sciences·B S JesuínoH Silveira
Nov 24, 2017·The Journal of Experimental Medicine·Stephen W ScallyJean-Philippe Julien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.