A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity

Human Molecular Genetics
Hagit KatzovJonathan A Prince

Abstract

Sequence variation in ACE, which encodes angiotensin I converting enzyme, contributes to a large proportion of variability in plasma ACE levels, but the extent to which this impacts upon human disease is unresolved. Most efforts to associate ACE with other heritable traits have involved a single Alu insertion/deletion polymorphism, despite the probable existence of other functional sequence variants with effects that may not be consistently detectable by solely typing the Alu indel. Here, utilizing single nucleotide polymorphisms (SNPs) that differentiate major ACE clades in European populations, we demonstrate a number of significant phenotype associations across more than 4000 Swedish individuals. In a systematic analysis of metabolic phenotypes, effects were detected upon several traits, including fasting plasma glucose levels, insulin levels and measures of obesity (P-values ranging from 0.046 to 8.4 x 10(-6)). Extending cladistic models to the study of myocardial infarction and Alzheimer disease, significant associations were observed with greater effect sizes than those typically obtained in large-scale meta-analyses based on the Alu indel. Population frequencies of ACE genotypes were also found to change with age, congru...Continue Reading

References

Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Mar 5, 1998·Clinical Science·R ButlerA D Struthers
Sep 16, 1998·Human Molecular Genetics·B KeavneyM Farrall
May 13, 1999·Nature Genetics·M J RiederD A Nickerson
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·H H WittrupB G Nordestgaard
Nov 5, 1999·Nature Genetics·M FarrallG M Lathrop
Sep 9, 2000·Journal of Medical Genetics·Y NarainD C Rubinsztein
Sep 23, 2000·American Journal of Human Genetics·X ZhuM J Rieder
May 22, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C J DobbelsteynG Flowerdew
Oct 5, 2001·Nature Genetics·G C JohnsonJ A Todd
Dec 13, 2001·American Journal of Human Genetics·Tianhua NiuJun S Liu
Jan 31, 2002·Nature Genetics·Ulrich BroeckelHeribert Schunkert
Aug 13, 2002·European Journal of Human Genetics : EJHG·Florent SoubrierMartin Farrall
Sep 7, 2002·Hypertension·Tetsuya ShiuchiMasatsugu Horiuchi
Sep 25, 2002·Journal of Internal Medicine·P LichtensteinN L Pedersen
Jan 7, 2003·Annals of Internal Medicine·Pasquale StrazzulloUNKNOWN Olivetti Prospective Heart Study
Jan 10, 2003·Nucleic Acids Research·D KarolchikUNKNOWN University of California Santa Cruz
Apr 1, 2003·IUBMB Life·Jacqueline M Matthews, Margaret Sunde
Apr 2, 2003·Human Molecular Genetics·Patrick G KehoeJonathan A Prince
May 23, 2003·Journal of Biology·Boris LenhardWyeth W Wasserman
May 27, 2003·Journal of Cellular Physiology·Erik J Henriksen, Stephan Jacob
Jun 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Patrick G Kehoe
Jun 24, 2003·The American Journal of Cardiology·Samy I McFarlaneJames R Sowers
Jun 26, 2003·Nucleic Acids Research·Luca CartegniAdrian R Krainer
Jul 16, 2003·Archives of Internal Medicine·Deborah GustafsonIngmar Skoog
Aug 14, 2003·Genome Biology·James F Riordan

❮ Previous
Next ❯

Citations

Jan 25, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P WangUNKNOWN Diogenes consortium
Sep 13, 2005·The Journal of Biological Chemistry·Matthew L Hemming, Dennis J Selkoe
Jun 29, 2011·Journal of Neurosurgical Anesthesiology·Jonatan Myrup StaalsøNiels Vidiendal Olsen
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·José A Luchsinger, Deborah R Gustafson
Mar 14, 2014·American Journal of Hypertension·Amelia A AssarehPerminder S Sachdev
Jul 31, 2010·Mediators of Inflammation·Carmela Rita BalistreriGiuseppina Candore
Dec 17, 2015·Clinical and Experimental Pharmacology & Physiology·Steven GrimsonRodney J Scott
Jun 27, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Antonio TorselloVittorio Locatelli
Jan 19, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Sayed Mohammad ShafieeAhmad Mohebbi
Jun 6, 2009·Ageing Research Reviews·Davide SeripaAlberto Pilotto
Apr 22, 2008·European Journal of Pharmacology·Deborah Gustafson
Dec 24, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Todd L EdwardsMarylyn D Ritchie
Jun 3, 2006·Obesity·Tuomo RankinenClaude Bouchard
Jul 3, 2010·Neurobiology of Aging·Rita J GuerreiroJohn Hardy
Apr 30, 2008·Genomics·Sahoko IchiharaYoshinori Nozawa
Dec 3, 2014·Brain Research Bulletin·Xiu-Zhen ZhangGuang-Yan Tang
Jun 29, 2017·The International Journal of Neuroscience·Hamdouni HaithemBouslama Ali
May 13, 2006·Circulation Research·F A Sayed-TabatabaeiJ C M Witteman
Jul 22, 2005·American Journal of Epidemiology·Donald J LehmannPatrick G Kehoe
Mar 5, 2009·Physiological Genomics·Silvia LacchiniJosé E Krieger
Aug 1, 2019·Archives of Endocrinology and Metabolism·Deborah de Farias LelisMarcelo Perim Baldo
May 27, 2021·Cognitive Neuropsychiatry·Fabricio Ferreira de OliveiraPaulo Henrique Ferreira Bertolucci

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