A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature

The Tohoku Journal of Experimental Medicine
Masahito HatoriShoichi Kokubun

Abstract

Adamantinoma is known as a low-grade malignant biphasic tumor. Classic adamantinoma is in general characterized by admixture of both epithelial and osteofibrous components that are associated with various proportions and differentiation patterns. Osteofibrous dysplasia (OFD) is a self-limited benign fibro-osseous lesion of bone during infancy and childhood. OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in which small groups of epithelial cells are only detected by careful search or immunohistochemistry. There have been controversies as to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma. We report an unusual case of adamantinoma arising in the tibia, with an extensive review of the literature. The present findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma. At the age of 12 years, the tibial biopsy lesion was diagnosed as OFD. At the age of 23, the lesion became larger and more destructive on x-ray films. The biopsy lesion was diagnosed as classic adamantinoma. Wide excision was performed. The primary lesion was retrospectively diagnosed as OFD-like adamantinoma because of presence of keratin-positive epithelial cells w...Continue Reading

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Citations

Dec 3, 2008·Pathology Oncology Research : POR·Miklós SzendroiGabriella Arató
Feb 28, 2008·The American Journal of Surgical Pathology·Briana C GleasonAntonio R Perez-Atayde
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Mar 1, 2012·Surgical Pathology Clinics·Jacquelyn A Knapik
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Jul 18, 2020·Journal of Orthopaedic Surgery and Research·Zhiping DengXiaohui Niu
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Oct 8, 2020·The Journal of Bone and Joint Surgery. American Volume·E M SchutgensUNKNOWN Adamantinoma Research Group

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