A classification method to distinguish cell-specific responses elicited by current pulses in hippocampal CA1 pyramidal cells

Neural Computation
José Ambros-IngersonWilliam R Holmes

Abstract

The suprathreshold electrophysiological responses of pyramidal cells have been grouped into large classes such as bursting and spiking. However, it is not known whether, within a class, response variability ranges uniformly across all cells or whether each cell has a unique and consistent profile that can be differentiated. A major difficulty when comparing suprathreshold responses is that slight variations in spike timing in otherwise very similar traces render traditional metrics ineffective. To address these issues, we developed a novel distance measure based on fiducial points to quantify the similarity among traces with trains of action potentials and applied it together with classification techniques to a set of in vitro patch clamp recordings from CA1 pyramidal cells. We tested if responses to repeated current stimulation of a given cell would cluster together yet remain distinct from those of other cells. We found that depolarizing and hyperpolarizing current pulses elicited responses in each cell that clustered and were systematically distinguishable from responses in other cells. The fiducial-point distance measure was more effective than other methods based on spike times and voltage-gradient phase planes. Depolarizi...Continue Reading

References

Oct 1, 1992·Physiological Reviews·W RallI Segev
Jan 1, 1990·Progress in Brain Research·J F Storm
Mar 1, 1988·The Journal of General Physiology·P SahP W Gage
Dec 1, 1989·Journal of Neuroscience Methods·M G BlantonA R Kriegstein
Sep 1, 1984·The Journal of Physiology·D V Madison, R A Nicoll
Jun 9, 1995·Science·Z F Mainen, T J Sejnowski
Nov 6, 1995·The Journal of Comparative Neurology·N IshizukaD G Amaral
Jun 12, 1997·Nature·S L HoffmanM J Morgan
Aug 1, 1997·Journal of Neurophysiology·N T CarnevaleT H Brown
Oct 9, 1999·Journal of Computational Neuroscience·M C Vanier, J M Bower
Jun 27, 2000·Biophysical Journal·L J GentetJ D Clements
Apr 22, 2004·The Journal of Comparative Neurology·Ruggero ScorcioniGiorgio A Ascoli
Oct 19, 2004·Hippocampus·José Ambros-Ingerson, William R Holmes
Nov 24, 2004·Nature Neuroscience·Astrid A PrinzEve Marder
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew M Swensen, Bruce P Bean
Aug 12, 2005·Journal of Neurophysiology·Naomi KerenAlon Korngreen
Sep 6, 2005·Current Opinion in Neurobiology·Jonathan D Victor
Jun 23, 2006·Nature Reviews. Neuroscience·Eve Marder, Jean-Marc Goaillard
Jul 20, 2006·PLoS Computational Biology·Pablo Achard, Erik De Schutter

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Citations

Jan 28, 2009·The Journal of Physiology·Naomi KerenAlon Korngreen

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