A Clerodane Diterpene from Callicarpa americana Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics.

ACS Infectious Diseases
Micah DettweilerCassandra L Quave

Abstract

The rise of antibiotic resistance presents a significant healthcare challenge and precludes the use of many otherwise valuable antibiotics. One potential solution to this problem is the use of antibiotics in combination with resistance-modifying agents, compounds that act synergistically with existing antibiotics to resensitize previously resistant bacteria. In this study, 12(S),16ξ-dihydroxycleroda-3,13-dien-15,16-olide, a clerodane diterpene isolated from the medicinal plant Callicarpa americana, was found to synergize with oxacillin against methicillin-resistant Staphylococcus aureus. This synergy was confirmed by checkerboard (fractional inhibitory concentration index (FICI) = 0.125) and time-kill assays, with a subinhibitory dose of 12(S),16ξ-dihydroxycleroda-3,13-dien-15,16-olide causing the effective concentration of oxacillin to fall below the susceptibility breakpoint for S. aureus, a >32-fold decrease in both cases.

References

Feb 1, 1978·The Journal of Infectious Diseases·M C Berenbaum
Mar 1, 1993·Antimicrobial Agents and Chemotherapy·K H RandD Bennett
Aug 1, 1996·Antimicrobial Agents and Chemotherapy·R L WhiteJ A Bosso
Nov 7, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E M Williamson
Aug 22, 2002·Archives of Microbiology·Brigitte Berger-Bächi, Susanne Rohrer
Jun 14, 2003·The Journal of Antimicrobial Chemotherapy·F C Odds
Feb 7, 2007·Journal of Natural Products·William P JonesA Douglas Kinghorn
Sep 2, 2009·Antimicrobial Agents and Chemotherapy·UNKNOWN International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC)
Jun 1, 2008·Current Bioactive Compounds·William P Jones, A Douglas Kinghorn
Oct 28, 2009·Phytochemistry·Courtney M StarksGary R Eldridge
Apr 26, 2011·Nature Chemical Biology·Linda EjimGerard D Wright
Jul 13, 2012·Natural Product Reports·Ana Cristina AbreuManuel Simões
Jul 21, 2012·Journal of Clinical Microbiology·Senda Mezghani MaalejAdnene Hammami
Mar 23, 2013·Current Opinion in Microbiology·Denise M Monack, Scott J Hultgren
Mar 28, 2013·The Journal of Organic Chemistry·Roberta J Worthington, Christian Melander
Apr 24, 2014·Molecular Cancer Therapeutics·Muhammad KashifMats G Gustafsson
Oct 21, 2015·Emerging Infectious Diseases·Margaret CarrelMichael Z David
May 11, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Vivek Kumar GuptaMahendra Pandurang Darokar
May 6, 2017·Clinical Pharmacology and Therapeutics·E J FilipponeJ L Farber
Sep 12, 2017·ACS Infectious Diseases·Arno Vermote, Serge Van Calenbergh
Sep 13, 2017·Journal of Medical Microbiology·Maria M Hryniewicz, Katarzyna Garbacz
Nov 5, 2019·Frontiers in Pharmacology·Rozenn M PineauCassandra L Quave

❮ Previous
Next ❯

Citations

Jan 26, 2021·Frontiers in Pharmacology·François ChassagneCassandra L Quave
Dec 30, 2020·Chemical Reviews·Jed F Fisher, Shahriar Mobashery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Bioactive Compounds
William P Jones, A Douglas Kinghorn
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
D JonasK J Towner
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
C CunyW Witte
© 2022 Meta ULC. All rights reserved