A clinical and endocrine study on the effect of orally administered bacterial endotoxin in adult pigs and goats

Zentralblatt für Veterinärmedizin. Reihe A
N CortR Rylander

Abstract

Endotoxin of Gram-negative bacteria was orally administered in 5 female pigs and 8 male goats. Two of the gilts were pregnant. A solution of lipopolysaccharide (LPS) of Enterobacter agglomerans was mixed into the feed ration of the pigs (40 mg/animal), and given by gastric tube into the rumen of the goats (1-20 mg/animal). Jugular venous blood was collected and clinical signs, rectal temperature and WBC counts were recorded for 12-24 hours. Plasma concentrations of the major plasma metabolite of PGF2 alpha, 15-keto-13,14-dihydro-PGF2 alpha were determined in both species, progesterone concentration only in pigs. The pigs showed slight to severe signs of endotoxemia. Increases in rectal temperature and levels of the PGF2 alpha metabolite occurred in 3 gilts. Progesterone level and the total WBC counts remained unchanged. Differential counts followed irregular patterns mostly within the normal range. The goats showed slight signs of discomfort. Temperature increased in one animal. No other parameters were altered after the intake of LPS. The observations in pigs indicate that endotoxin either penetrated the intestinal barrier causing systemic endotoxemia or induced inflammatory reactions in the intestine activating inflammatory m...Continue Reading

References

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Citations

Feb 1, 1993·Zentralblatt für Veterinärmedizin. Reihe A·H HolstR Rylander
Nov 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·M BekanaH Kindahl
Jan 16, 2016·Environmental Health : a Global Access Science Source·R John WallaceLubomir Leng
Sep 15, 2009·Theriogenology·R HagmanH Kindahl
Jan 25, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·K L BidneA F Keating
May 7, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel)Fernando Ramos
Mar 21, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel)Fernando Ramos
May 2, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Gloria López-Gálvez
Feb 28, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Sep 3, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Oct 25, 2018·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Robert John Wallace
Sep 3, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fernando Ramos
Jul 25, 2017·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Robert John Wallace
May 3, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel)Fernando Ramos
Mar 19, 2021·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Jordi Tarrés-Call
May 1, 2021·Toxins·Haoming WuJiaqi Wang

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