A clinical approach to early-onset inheritable dementia

American Journal of Alzheimer's Disease and Other Dementias
Brian S Rogers, Carol F Lippa

Abstract

Early-onset dementia, presenting before age 65 years, is increasingly recognized. It is often difficult to diagnose, since non-Alzheimer's etiologies and unusual dementias are common. These conditions are more commonly genetic, and important potentially inherited causes of early-onset dementia include early-onset Alzheimer's disease, frontotemporal dementia, Kufs' disease, and Niemann-Pick disease type C. For each of these diseases, this review provides information on common clinical presentations, etiology, pathophysiology, and current and experimental treatments. A discussion of the diagnosis and workup for early-onset dementia is included with an emphasis on conditions that may have other involved family members.

References

Feb 15, 1992·American Journal of Medical Genetics·K E WisniewskiJ Heaney-Kieras
Feb 1, 1988·Brain : a Journal of Neurology·S F BerkovicL S Wolfe
May 1, 1995·Neurobiology of Aging·H Braak, E Braak
Jun 5, 1995·American Journal of Medical Genetics·N NardocciO Bugiani
Apr 1, 1994·Journal of Medical Genetics·S J SteinbergA H Fensom
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D E SchmechelA D Roses
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Jun 1, 1997·Brain : a Journal of Neurology·T Edwards-LeeI Mena
Feb 25, 1999·International Journal of Geriatric Psychiatry·R CacabelosB Winblad
Aug 20, 2003·Archives of Neurology·Liesi E HebertDenis A Evans
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·R J HarveyM N Rossor
Sep 6, 2003·American Journal of Alzheimer's Disease and Other Dementias·Rita MorettiAntonio Bava
Jan 24, 2004·Dementia and Geriatric Cognitive Disorders·Manabu IkedaHirotaka Tanabe
Mar 3, 2004·Annals of Neurology·Maria Luisa Gorno-TempiniBruce L Miller
Nov 24, 2004·Drugs & Aging·Rita MorettiAntonio Bava
Feb 24, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Cristina S IvanJeff M Milunsky
Apr 27, 2005·Neurology·W W SeeleyH J Rosen
Dec 30, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Mario F MendezEliot Licht
Apr 25, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andreas FellgiebelMatthias Schreckenberger
Jun 5, 2007·Alzheimer Disease and Associated Disorders·Margaret M Swanberg
Jul 4, 2007·American Journal of Alzheimer's Disease and Other Dementias·Eliot A LichtMario F Mendez
Aug 11, 2007·Lancet Neurology·Marc C PattersonJames E Wraith
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong-Jie ZhangLeonard Petrucelli
Jan 17, 2008·Dementia and Geriatric Cognitive Disorders·A KerteszR Brashear
Oct 2, 2009·Nature Reviews. Drug Discovery·Kurt R BrundenVirginia M-Y Lee
Nov 27, 2009·Current Alzheimer Research·V FrisardiF Panza
Jan 5, 2010·Molecular Genetics and Metabolism·James E WraithMarc C Patterson
Jan 13, 2010·The Neurologist·Zoe Arvanitakis
Jun 8, 2010·Orphanet Journal of Rare Diseases·Marie T Vanier
Dec 16, 2010·International Journal of Geriatric Psychiatry·Edward RenvoizeMark Dale
Mar 5, 2011·Lancet·Clive BallardEmma Jones

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Citations

Aug 9, 2012·American Journal of Alzheimer's Disease and Other Dementias·Mario F MendezJill S Shapira
Sep 26, 2013·Journal of Neural Transmission·Ke-Sheng WangChun Xu
Oct 30, 2016·Journal of Alzheimer's Disease : JAD·Chiara CupidiAmalia Cecilia Bruni
Sep 20, 2012·American Journal of Alzheimer's Disease and Other Dementias·Natalie C KaiserMario F Mendez
Feb 20, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Olivier BonnotMark Walterfang
Sep 16, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Olivier BonnotMarc C Patterson

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Methods Mentioned

BETA
electron microscopy
biopsy
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