PMID: 28990Jan 1, 1978Paper

A clinical comparison of triazolam with placebo and with secobarbital in insomniac patients

The Journal of International Medical Research
K K Okawa, G S Allens


Seventy-six out-patient insomniacs participated in three different two-night, double-blind crossover trials investigating the hypnotic efficacy andsafety of triazolam. Triazolam 0.5 mg was compared to placebo in one trial conducted K Kay Okawa, MD, and triazolam 0.5 mg was compared to secobarbital 100 mg in trials conducted by K Kay Okawa, MD and George S Allen, MD. The results of the later two studies were combined and the data analyzed jointly. Triazolam 0.5 mg was found to be preferred and to be significantly better than both placebo and secobarbital 100 mg in the treatment of insomnia. Analysis of sleep questionnaire data showed triazolam to be superior to either placebo or secobarbital on the following parameters: how much the medication helped the patients sleep; onset of sleep; duration of sleep; and number of nocturnal awakenings. No differences were observed between treatments in any trial with regard to the patient's feeling of alertness the next morning. The side-effects reported for all treatments did not significantly interfere with the patient's ability to function.


Jan 1, 1975·Psychopharmacologia·G VogelK Sexton
Sep 11, 1975·Clinical Pharmacology and Therapeutics·K RickelsA Schilling
Dec 22, 1966·The New England Journal of Medicine·H JickH Muench


May 1, 1983·Pharmacotherapy·T RothF Zorick
Jan 1, 1981·British Journal of Clinical Pharmacology·R P Purpura
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·P D Kroboth, R P Juhl
Mar 7, 2006·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Russell P Rosenberg

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Clinical Trials
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