A clinical genetic method to identify mechanisms by which pain causes depression and anxiety.

Molecular Pain
Mitchell B MaxInna Belfer

Abstract

Pain patients are often depressed and anxious, and benefit less from psychotropic drugs than pain-free patients. We hypothesize that this partial resistance is due to the unique neurochemical contribution to mood by afferent pain projections through the spino-parabrachial-hypothalamic-amygdalar systems and their projections to other mood-mediating systems. New psychotropic drugs for pain patients might target molecules in such brain systems. We propose a method to prioritize molecular targets by studying polymorphic genes in cohorts of patients undergoing surgical procedures associated with a variable pain relief response. We seek molecules that show a significant statistical interaction between (1) the amount of surgical pain relief, and (2) the alleles of the gene, on depression and anxiety during the first postoperative year. We collected DNA from 280 patients with sciatica due to a lumbar disc herniation, 162 treated surgically and 118 non-surgically, who had been followed for 10 years in the Maine Lumbar Spine Study, a large, prospective, observational study. In patients whose pain was reduced >25% by surgery, symptoms of depression and anxiety, assessed with the SF-36 Mental Health Scale, improved briskly at the first pos...Continue Reading

References

Jan 1, 1996·Progress in Brain Research·R Burstein
Sep 24, 1999·Current Medical Research and Opinion·N BellamyJ Syrotuik
Feb 1, 2000·Biologicals : Journal of the International Association of Biological Standardization·L ShiY Xu
Feb 26, 2000·Trends in Pharmacological Sciences·T A BranchekM W Walker
Dec 22, 2000·Spine·J E Ware
May 11, 2001·Annals of Internal Medicine·K Kroenke, L Harris
Oct 6, 2001·The Clinical Journal of Pain·E J Carragee
Aug 6, 2002·Science·Avshalom CaspiRichie Poulton
Jan 24, 2003·International Journal of Epidemiology·Smita L S HalderGary J Macfarlane
Nov 13, 2003·JAMA : the Journal of the American Medical Association·Elizabeth H B LinUNKNOWN IMPACT Investigators
Dec 17, 2003·Biological Psychiatry·Jordan W SmollerSusan A Slaugenhaupt
Jan 30, 2004·Psychosomatic Medicine·Matthew J BairKurt Kroenke
May 12, 2004·Peptides·David M JacobowitzGerhard Skofitsch
May 27, 2004·The Journal of Pain : Official Journal of the American Pain Society·Francis J KeefeLisaCaitlin M Perri
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiaoying LuTamas Bartfai
Feb 9, 2005·Archives of General Psychiatry·Ahmad R HaririDaniel R Weinberger
Mar 17, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xueying JiangRobert H Lipsky
Apr 30, 2005·Biological Psychiatry·Sandra López LeónCornelia M van Duijn
May 4, 2005·Archives of General Psychiatry·Terrie E MoffittMichael Rutter
Jun 10, 2005·Neuropeptides·G Barreda-GómezR Rodríguez-Puertas
Jun 14, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Klaus Peter Lesch, Lise Gutknecht
Jul 28, 2005·The Journal of Biological Chemistry·Ying ZhangWolfgang Sadée
Aug 25, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Christa HohoffHarriet de Wit
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chad J SwansonTheresa A Branchek
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeong S HanVolker Neugebauer

❮ Previous
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Citations

Sep 7, 2007·CNS Spectrums·Dan J SteinJaak Panksepp
Jan 19, 2011·Current Neurology and Neuroscience Reports·Marcelo E Bigal, Richard B Lipton
Jun 23, 2012·Pharmacogenetics and Genomics·Anne Tammimäki, Pekka T Männistö
Nov 28, 2013·Scientifica·Inna Belfer
Feb 20, 2019·Cell and Tissue Research·Muris HumoIpek Yalcin
Jan 6, 2009·Annals of the New York Academy of Sciences·Mbemba JabbiJohan A den Boer
Jan 11, 2011·European Journal of Pain : EJP·Oleg KamburVesa K Kontinen
Dec 6, 2007·Expert Review of Neurotherapeutics·Jeanne Leventhal AlexanderJeffrey J Sherman
Sep 17, 2011·Pharmacogenomics·Shinya Kasai, Kazutaka Ikeda
Jun 22, 2012·Pain·Barbara A HastieRoger B Fillingim
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Justin C McArthur
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gabriella JuhaszGyorgy Bagdy
Jan 27, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C DavisJ L Kennedy
Oct 19, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·H SalfingerM Friedrich
Feb 12, 2015·Psychiatry Investigation·Changsu Han, Chi-Un Pae
May 2, 2012·Current Opinion in Neurology·Christina I DeligianniDimos D Mitsikostas
Dec 24, 2008·Human Molecular Genetics·Svetlana A ShabalinaLuda Diatchenko
Nov 12, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Deborah BarrettMark J Edlund
Dec 7, 2020·BMC Musculoskeletal Disorders·Der-Shin KeChia-Hung Kao
Feb 24, 2016·The Journal of Pain : Official Journal of the American Pain Society·Manuela De GregoriMassimo Allegri

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Methods Mentioned

BETA
PCR
environmental stress
DNA collection
genotyping

Software Mentioned

SNP Browser
Panther
SAS

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