A clinical, histopathologic, and outcome study of melanonychia striata in childhood

Journal of the American Academy of Dermatology
Chelsea CooperPedram Gerami

Abstract

The current literature suggests that approximately 5% to 10% of melanonychia striata cases in adults are the result of subungual melanoma. We sought to evaluate the clinical and histopathologic features and to determine the outcomes and causes of melanonychia striata in a cohort of children. We assessed 30 childhood cases of melanonychia striata for features typically associated with melanoma such as Hutchinson sign, width of the pigmented band, evolution, color, and nail dystrophy. We assessed the histopathology of lesional biopsy specimens, including melanocyte counts and suprabasal movement of melanocytes. Clinical follow-up information was reviewed when available. Histopathologic diagnoses included subungual lentigo in 20 cases, subungual nevus in 5 cases, and atypical melanocytic hyperplasia in 5 cases. Although a number of cases exhibited worrisome clinical or histopathologic features, none showed evidence of aggressive behavior or warranted a diagnosis of melanoma. The sample size and follow-up times are limited. Melanonychia striata is typically associated with benign stable melanocytic proliferations in childhood. The overwhelming majority of cases can be managed conservatively. Biopsy is required in select cases.

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Citations

Jan 23, 2016·Annales de dermatologie et de vénéréologie·I Moulonguet, S Goettmann-Bonvallot
May 15, 2016·Journal of the American Academy of Dermatology·Jungyoon OhnJe-Ho Mun
Oct 3, 2017·Pediatric Dermatology·Esther BurkinkHerm Martens
Apr 23, 2019·International Journal of Dermatology·Alexander K C LeungConsolato M Sergi
Oct 3, 2019·Pediatric Dermatology·WeiXuan Colin TanSiong See Joyce Lee
Dec 19, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·C StefanakiG Kontochrostopoulos
Aug 15, 2017·Pediatric Dermatology·Austin John Maddy, Antonella Tosti
Apr 28, 2017·The Journal of Dermatology·Hiroshi Koga
Jul 9, 2020·Journal of Cutaneous Pathology·Pembegül GüneşEckart Haneke
Oct 16, 2018·Journal of the American Academy of Dermatology·Oriol YélamosAshfaq A Marghoob
Jan 20, 2021·Actas dermo-sifiliográficas·E Ríos-ViñuelaC Requena
Mar 23, 2021·Dermatologic Clinics·Jane Sanders Bellet
Mar 23, 2021·Dermatologic Clinics·Beth S Ruben
Nov 23, 2020·Journal of the American Academy of Dermatology·Jongeun LeeEun Ji Kwon
Jun 1, 2021·Actas dermo-sifiliográficas·E Ríos-ViñuelaC Requena
Jul 16, 2021·Pediatric Dermatology·Jane Sanders Bellet
Oct 29, 2021·Pediatric Dermatology·Krystal N MitchellNanette B Silverberg

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