A clinical overview of familial adenomatous polyposis derived from the database of the Polyposis Registry of Japan

International Journal of Clinical Oncology
Takeo IwamaJapanese Society for Cancer of the Colon and Rectum

Abstract

The clinical situation of familial adenomatous polyposis (FAP) in Japan has changed in the period since the last analysis of data of the Japanese Polyposis Center. To reevaluate our data and elucidate the changes we analyzed the records of the 1390 FAP patients in 900 families registered with the Polyposis Committee of the Japanese Society for Cancer of the Colon and Rectum. In the 13-year period 1990-2003, clinical differences between men and women with FAP diminished. The postoperative prognosis was substantially better in patients without advanced colorectal cancer (stage > or = T2) than in those with early cancer or no cancer. Mean age at death improved from 42.5 years in the period before 1990 to 46.0 years, and it was a result of a decreased proportion of deaths from colorectal cancer. The distribution of colorectal cancer in FAP patients was similar to that in the general population. Desmoid tumors accounted for about 10% of deaths in the recent 13 years (1990-2003). The cumulative risk of rectal cancer in the preserved rectum was 12% at 10 years and 23% at 15 years. The registry system in Japan revealed a new clinical situation in FAP patients, and the findings of this study will be useful to improve the prognosis of pa...Continue Reading

Citations

Sep 4, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fabio Guilherme CamposIvan Cecconello
May 22, 2007·Current Gastroenterology Reports·Steven H Erdman
Apr 25, 2013·Japanese Journal of Clinical Oncology·Masami KomiyaMichihiro Mutoh
Aug 3, 2013·Japanese Journal of Clinical Oncology·Hideyuki IshidaJunichi Tamaru
Mar 21, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Takeo Iwama
Aug 3, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fábio Guilherme C M de CamposIvan Cecconello
Dec 19, 2013·International Journal of Clinical Oncology·Mina Morii-KashimaHiroaki Shibahara
Jan 29, 2016·Japanese Journal of Clinical Oncology·Tatsuro YamaguchiKenichi Sugihara
Dec 18, 2015·Surgery Today·Keisuke HataToshiaki Watanabe
Sep 14, 2015·Surgical Oncology Clinics of North America·Kory Jasperson, Randall W Burt
Jul 16, 2016·Japanese Journal of Clinical Oncology·Yasuhiro InoueKenichi Sugihara
Mar 17, 2010·Arquivos De Gastroenterologia·Fábio Guilherme CamposIvan Cecconello
Feb 4, 2006·The American Journal of Gastroenterology·Polymnia Galiatsatos, William D Foulkes
Jun 17, 2016·Journal of Clinical Gastroenterology·Tatsuo YachidaYutaka Saito
Aug 15, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kaoru NakanoJunko Fujisaki
Sep 14, 2016·The Journal of Clinical Endocrinology and Metabolism·Shinya UchinoToshiyuki Sakai
May 25, 2018·Journal of the Anus, Rectum and Colon·Hideyuki IshidaUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Aug 24, 2017·International Journal of Colorectal Disease·Masahiro TanakaKenichi Sugihara
Sep 19, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yasuhiro MitsuiTetsuji Takayama
Jun 1, 2021·Gastrointestinal Endoscopy Clinics of North America·Sheila D RustgiFay Kastrinos
Jul 2, 2021·Clinical Case Reports·Kosuke SaitoKenji Okami
Jun 30, 2021·International Journal of Clinical Oncology·Naohiro TomitaUNKNOWN Japanese Society for Cancer of the Colon, Rectum
Jun 20, 2021·Gastrointestinal Endoscopy·Yusaku ShimamotoHideki Ishikawa

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