A clinical overview of pheochromocytomas/paragangliomas and carcinoid tumors.

Nuclear Medicine and Biology
Ioannis Ilias, Karel Pacak

Abstract

Pheochromocytomas/paragangliomas are rare tumors; most are sporadic. Biochemical proof of disease is better with measurement of plasma metanephrines and less cumbersome than determinations in urine; its implementation is expanding. Anatomical imaging with computed tomography or magnetic resonance imaging should be followed by functional (nuclear medicine) imaging: chromaffin tumor-specific methods are preferred. Treatment is surgical; for nonoperable disease other options are available. Overall 5-year survival is 50%. Carcinoid tumors derive from serotonin-producing enterochromaffin cells in the fore-, mid- or hindgut. Biochemical screening (and follow-up) is done with measurements of 5-hydroxyindoloacetic acid in urine. For most carcinoids, functional imaging is better than other modalities in localizing primary tumors. Surgery is the treatment of choice; nonresectable tumors are treated with somatostatin analogs or chemotherapy. Overall 5-year survival for patients with carcinoids is 67%.

References

Mar 4, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·F F TelischiT J Balkany
Sep 14, 2000·The Urologic Clinics of North America·J H Ross
Jan 31, 2002·Radiology·Stefan HoegerleHartmut P H Neumann
Sep 13, 2002·The New England Journal of Medicine·James A Strauchen
Oct 17, 2002·Annals of the New York Academy of Sciences·Barbro ErikssonBengt Långström
Nov 30, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Matthias SchmidtHarald Schicha
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Graeme EisenhoferKarel Pacak
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Jochen MundschenkHendrik Lehnert
Jan 31, 2004·Radiology·Carlos TrampalBengt Långström
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ioannis Ilias, Karel Pacak
Mar 19, 2004·Endocrine-related Cancer·M T BarakatS R Bloom
Apr 20, 2004·The Laryngoscope·A BustilloM Whiteman
Oct 19, 2004·World Journal of Surgery·Mark S SywakOtto Rorstad
Jan 11, 2005·Clinical Journal of Oncology Nursing·Michele E Gaguski
Jan 13, 2005·The Journal of Clinical Endocrinology and Metabolism·Laurence AmarPierre-François Plouin
Feb 15, 2005·The Oncologist·Johanna M Zuetenhorst, Babs G Taal
Dec 3, 2005·Endocrine-related Cancer·G A KaltsasA B Grossman
Jul 29, 2006·Circulation Research·Christina A PacakBarry J Byrne
Nov 15, 2006·Annals of the New York Academy of Sciences·William F Young
Nov 15, 2006·Annals of the New York Academy of Sciences·Diana E BennBruce G Robinson
Nov 15, 2006·Annals of the New York Academy of Sciences·Susannah Cleary, Jacqueline K Phillips
Nov 15, 2006·Annals of the New York Academy of Sciences·Ashley GrossmanGraeme Eisenhofer
Nov 15, 2006·Annals of the New York Academy of Sciences·Barry L ShulkinKarel Pacak
Nov 15, 2006·Annals of the New York Academy of Sciences·Laurence AmarPierre-François Plouin
Nov 15, 2006·Annals of the New York Academy of Sciences·Massimo Mannelli
Nov 15, 2006·Annals of the New York Academy of Sciences·Andreas MachensHenning Dralle
Nov 15, 2006·Annals of the New York Academy of Sciences·Amir Khorram-ManeshHåkan Ahlman
Nov 15, 2006·Annals of the New York Academy of Sciences·Håkan Ahlman
Nov 15, 2006·Annals of the New York Academy of Sciences·Paul A FitzgeraldKatherine K Matthay
Nov 15, 2006·Annals of the New York Academy of Sciences·Lars KölbyHåkan Ahlman
Nov 15, 2006·Annals of the New York Academy of Sciences·James C SissonNazanene H Esfandiari
Dec 15, 2006·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·M A RaffertyM A Walsh
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Günter Klöppel
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Wouter W de Herder
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Andrea G Rockall, Rodney H Reznek
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Göran Akerström, Per Hellman
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael GabrielIrene J Virgolini
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henri J L M TimmersKarel Pacak
Jun 6, 2007·Hematology/oncology Clinics of North America·Eric P TammChaan S Ng
Jun 6, 2007·Hematology/oncology Clinics of North America·Matthew H Kulke

❮ Previous
Next ❯

Citations

Aug 12, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Meeran NajiAdil Al-Nahhas
Nov 3, 2009·Cancer Biotherapy & Radiopharmaceuticals·Ernst J Postema, Alexander J B McEwan
Apr 11, 2014·International Journal of Endocrinology and Metabolism·Evangelia Skoura
Nov 10, 2011·Langenbeck's Archives of Surgery·Pierre de WaillyJean Louis Kraimps
Mar 1, 2013·Nuclear Medicine and Molecular Imaging·Eun Ji HanLee-So Maeng
May 29, 2012·Clinical Radiology·K K WongD Rubello
Feb 8, 2011·European Journal of Radiology·Ka Kit WongMilton D Gross
Apr 3, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Gavin Low, Kamal Sahi
Feb 11, 2015·Oncology Letters·Huseyin Kazim BektasogluMahmut Muslumanoglu
Oct 30, 2016·Revista española de medicina nuclear e imagen molecular·K K WongD Rubello
Jan 20, 2011·Toxicology and Industrial Health·Angela SanciniFrancesco Tomei
Mar 13, 2015·Neurointervention·Tatiana Chacón-QuesadaTodd Trier
Jan 1, 2015·Journal of Diabetes and Metabolic Disorders·Akbar SoltaniBabak Mostafazadeh Davani
Jun 3, 2015·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·L H B BaurE B Gomez Garcia
Jul 27, 2018·The British Journal of Radiology·Archi AgrawalNilendu Purandare
Dec 5, 2013·Clinical Nuclear Medicine·Alessandra BaccaGiampaolo Bernini
Apr 24, 2010·Annals of the Royal College of Surgeons of England·Miguel Angel Arrabal-PoloArmando Zuluaga-Gomez
Jul 1, 2014·Endocrine Reviews·Ka Kit WongMilton D Gross
Sep 11, 2020·Clinical Nuclear Medicine·Yuanyuan JiangWuying Cheng
Jan 1, 2015·Journal of Diabetes and Metabolic Disorders·M PourianA Soltani
May 10, 2017·Endocrine·Emilia SbardellaAshley B Grossman
Jun 23, 2020·Medicine·Chenshan JiangBing Cai
Jun 27, 2019·Internal and Emergency Medicine·Brett Stephen Mansfield, Reyna Daya
Mar 30, 2021·Journal of Medical Case Reports·Robin Raquel RodriguezGene Grant Finley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

Clinical Endocrinology
Robin P F DullaartKlaas Pieter Koopmans
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Heikki MinnPirjo Nuutila
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Ioannis Ilias, Karel Pacak
© 2022 Meta ULC. All rights reserved